The BRPF2/BRD1-MOZ complex is involved in retinoic acid …
2016年8月1日 · Among several subunits comprising HAT complexes, scaffolding proteins are critical for proper enzymatic activity. The scaffold protein BRPF2 (also called BRD1), a …
Crystal structure of the BRPF2 PWWP domain in complex with …
Our crystal structure of the BRPF2 PWWP domain in complex with a 12-mer dsDNA reveals that the PWWP domain interacts with dsDNA by binding to its major groove, instead of the minor …
Structural and mechanistic insights into regulation of HBO1 …
2017年6月2日 · BRPF2 has been shown to be important for the HAT activity of HBO1 toward H3K14. Here we demonstrated that BRPF2 can regulate the HAT activity of HBO1 toward free …
The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of ...
2011年9月1日 · The histone acetyltransferases (HATs) of the MYST family include TIP60, HBO1, MOZ/MORF, and MOF and function in multisubunit protein complexes. Bromodomain …
Crystal structure of the BRPF2 PWWP domain in complex with …
2021年3月1日 · Structural comparison of our BRPF2-dsDNA complex with the LEDGF-nucleosome complex structure (PDB ID: 6S01) indicated that the PWWP domain could …
丁建平研究组揭示支架蛋白BRPF2调控组蛋白乙酰转移酶HBO1活 …
2017年4月10日 · 另外，体内实验结果也证明了brpf2的n端区域是hbo1-brpf2相互作用的重要位点，同时该区域也能够在一定程度上辅助该复合物结合核小体。 这些研究结果不仅揭示 …
Molecular Insights into the Recognition of Acetylated Histone ...
2022年9月6日 · Moreover, the BRPF2 bromodomain could enrich H4K5ac mark-bearing mononucleosomes compared to other acetylated H4 marks. Consistent with this, ChIP-seq …
Structural and mechanistic insights into regulation of HBO1 …
As expected, BRPF2 (1–205) can bind tightly to the HBO1 MYST domain. Intriguingly, BRPF2 (1–80) and BRPF2 (31–80) can also bind to HBO1 comparable to BRPF2 (1–205), whereas …
BRPF1新型转录本BRPF2的鉴定及其在小鼠组织中的表达
结果表明BRPF2是BRPF1的一种新型转录本(GenBank登录号：DQ288860); 在小鼠肝、胚胎、附睾、睾丸、卵巢和骨骼肌中均检测到 BRPF1和BRPF2两个转录本, 其中以BRPF1为主要的转 …
Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 …
2017年5月5日 · For BRPF2 and TAF1, experiments were performed in buffer (20 mM Hepes pH 7.5, 100 mM NaCl) on a VP-ITC microcalorimeter (MicroCal) at 20 °C. For CREBBP and …