2016年11月30日 · Although this model is heavily used in cachexia research, different approaches make reproducibility a potential issue. The growth of the C26 tumor causes a marked and progressive loss of body and skeletal muscle mass, accompanied by reduced muscle cross-sectional area and muscle strength 3-5. Adipose tissue is also lost.

In C26 cachexia, a shift towards smaller cross-sectional areas is observed in both glycolytic and oxidative fibers 2. This is also consistent with reduced muscle strength 5. Many groups worldwide have taken advantage of the C26 model in order to discover new mediators of muscle wasting or clinically relevant drugs for cancer cachexia.

2024年11月1日 · The animal model of C26 cachexia is modeled by subcutaneous inoculation of C26 cells into BALB/c mice unilaterally at a typical inoculation rate of 5 × 10 5 –1 × 10 6 cells per mouse. 12, 13 The severity of C26-induced cachexia depends on the number of cell passages, the inoculation volume, and the injection site. 23, 24 Anorexia does not occur when C26 cells are injected subcutaneously or ...

2021年11月13日 · CT-26 and Colon 26 syngeneic tumor models showed different sensitivity to anti-PD-1 therapy, although both tumor cells are murine colorectal carcinoma cell lines from BALB/c strain. By characterizing the mouse cells lines and tumor-immune context in the tumor tissues with comprehensive analysis appr …

摘要. 目的 观察C26腺癌恶病质动物模型的自然发展过程.方法 于BALB/C小鼠接种结肠腺癌Colon26( C26)细胞,在接种后0、5、10、15、20、25 d,记录小鼠腓肠肌、附睾和去瘤体质量,检测生化指标、肿瘤坏死因子-α( TNF-α)和组织核因子-KB(NF-KB)及泛素蛋白酶体的E3连接酶(Arogin)-1和肌肉环状指蛋白(MURF)-1基因的表达 ...

2016年11月30日 · Indiana University School of Medicine. Mice bearing the Colon-26 (C26) carcinoma represent a classical model of cancer cachexia. Progressive muscle wasting occurs in association with tumor growth, over-expression of muscle-specific ubiquitin ligases, and reductions in muscle cross-sectional area. Fat loss is also observed. Cachexia is studied in a time-dependent manner with increasing severity ...

2016年11月30日 · Indiana University School of Medicine. Mice bearing the Colon-26 (C26) carcinoma represent a classical model of cancer cachexia. Progressive muscle wasting occurs in association with tumor growth, over-expression of muscle-specific ubiquitin ligases, and reductions in muscle cross-sectional area. Fat loss is also observed. Cachexia is studied in a time-dependent manner with increasing severity ...

In C26-bearing mice, the dystrophin complex is downregulated, a phenomenon essential for wasting, thereby highlighting a regulatory role of dystrophin in cachexia . By exploiting the C26 model, we demonstrated that Peg3/PW1 and p53 participate in a positive feedback loop that regulates cachexia and stem cell numbers in skeletal muscle .

2010年7月8日 · Mice bearing ectopically-implanted C26 colon carcinoma are widely used as an experimental model of cancer cachexia. As part of the search for novel clinical and basic research applications for this experimental model, we characterized novel cellular and molecular features of C26-bearing mice.

Mice bearing the Colon-26 (C26) carcinoma represent a classical model of cancer cachexia. Progressive muscle wasting occurs in association with tumor growth, over-expression of muscle-specific ubiquitin ligases, and reductions in muscle cross-sectional area. Fat loss is also observed. Cachexia is studied in a time-dependent manner with ...