TL2-C29 binds a pocket in the BB loop within the TLR2 TIR domain, thereby inhibiting TLR2 interaction with the MyD88 adapter molecule and downstream MAPK and NF-κB activation [1]. In human TLR2 signaling, TL2-C29 blocks both TLR2/1 and TLR2/6 pathways.

C29 (25 或 50 μM；1 小时) 显著降低原代小鼠巨噬细胞中 P3C 诱导而非 P2C 诱导的 TNF-α mRNA 和 IL-12 p40 蛋白 。 C29 (50 μM；1 小时) 在 HEK-TLR2 细胞和小鼠巨噬细胞中阻断 TLR2 细菌激动剂诱导的促炎基因表达 。 MCE has not independently confirmed the accuracy of …

2015年4月28日 · C29, and its derivative, ortho-vanillin (o-vanillin), inhibited TLR2/1 and TLR2/6 signaling induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signaling in murine macrophages. C29 failed to inhibit signaling induced by other TLR agonists and TNF-α.

TL2-C29 binds a pocket in the BB loop within the TLR2 TIR domain, thereby inhibiting TLR2 interaction with the MyD88 adapter molecule and downstream MAPK and NF-κB activation1. In human TLR2 signaling, TL2-C29 blocks both TLR2/1 and TLR2/6 pathways. In murine TLR2 signaling, TL2-C29 preferentially blocks the TLR2/1 pathway1. 1. Mistry, P. et ...

C29 is an inhibitor of toll-like receptor 2 (TLR2) signaling. 1 It inhibits synthetic and bacterial TLR2 agonist-induced TLR2/1 and TLR2/6 signaling in HEK-293T cells expressing human TLR2 (HEK-TLR2) and THP-1 cells when used at a concentration of 50 µM. C29 also inhibits TLR2/1 signaling in primary murine macrophages without inducing ...

Here, we characterized the TLR2 antagonists MMG-11 and CU-CPT22 as well as the TIR-domain binding TLR2 antagonist C29 in TLR-overexpressing promoter cells as well as human and mouse macrophages. In line with our recent studies, MMG-11 abrogated pro-inflammatory cytokine secretion and NF-κB activation induced by different bacterial TLR2 agonists.

Hydroxychloroquine是一种有效的自噬流动性抑制剂 (autophagic flux inhibitor) ，具有抗病毒活性 (如 SARS-CoV-2 病毒)， 可以抑制 Toll 样受体 7/9 (TLR7 /9) 信号传导。 C29 是一种 Toll-like receptor 2 (TLR2) 抑制剂。 C29 阻断 hTLR2/1 和 hTLR2/6 信号， IC50 值分别为 19.7 和 37.6 μM。 Hydroxychloroquine sulfate (HCQ sulfate) 是一种合成的抗疟疾剂，也可以抑制 Toll 样受体 7/9 (TLR7 /9) 信号传导。

C29 是一种 Toll-like receptor 2 (TLR2) 抑制剂，可阻断 hTLR2/1 和 hTLR2/6 信号。 产品性质. CAS号 (CAS NO.) 运输和保存方法. 粉末-25~-15℃保存，有效期3年；溶于溶剂，-85~-65℃ …