2019年8月20日 · We find that C3 protein accumulates in synapses in human AD brains with tau pathology. Furthermore, intact and processed C3 levels are increased in cerebrospinal fluid (CSF) from AD patients and correlate with tau levels, informing potential therapeutic strategies for targeting complement in AD.

胶质纤维酸性蛋白 (gfap) 是构成 cns 中星形胶质细胞的细胞骨架的一种 iii 类中间纤丝。gfap 建立并维持星形胶质细胞形态，并且对有丝分裂以及神经元-星形胶质细胞通信非常重要。检测 gfap 的抗体通常用于标记星形胶质细胞并揭示其在大脑中的独特形态。

2022年3月29日 · Studies have shown that proinflammatory microglia can polarize astrocytes (designated A1 astrocytes) toward a neurotoxic phenotype characterized by increased Complement Component 3 (C3)...

胶质纤维酸性蛋白（Glail fibrillary acidicprotein,GFAP）是一种Ⅲ型中间纤维蛋白,主要存在于成熟的星形胶质细胞内,是星形胶质细胞的重要组成部分,也是主要的细胞骨架，除了在神经系统星形胶质细胞内高量表达外，GFAP在软骨细胞、成纤维细胞、肌上皮细胞、淋巴细胞、肝星形细胞也有表达，中间纤维蛋白在大脑的不同发育时期,其表达形式也存在差异，GFAP的表达受多种因素的影响，例如脑损伤和神经性肿瘤等疾病。 GFAP与神经性疾病. 胶质纤维酸性蛋白星形细胞 …

2024年3月1日 · Since C3 has been shown to mediate pro-inflammatory responses, we also evaluated the postoperative change in astrocytes and in cytokines after C3 inhibition. Firstly, GFAP and C3 double staining showed that AAV9-mediated C3 suppression occurred only within hippocampal astrocytes of postsurgical mice but not in those exposed to sevoflurane only ...

2019年5月22日 · To confirm the differences in C3 protein levels, we performed double staining of C3 and GFAP in brains of another set of terminally sick mice (Fig. 4b). While GFAP immunoreactivity was unchanged between prion diseased TKO- and WT-mice, C3 was significantly less upregulated in terminally sick TKO-mice (Fig. 4c ).

After pain behavior observation, the expression of glial fibrillary acidic protein (GFAP) in the medullary dorsal horn was observed by immunohistochemistry and immunofluorescence colocalization of GFAP, complement 3 (C3)/S100A10, and 4’, …

一位有远期视神经炎病史的进行性多发性硬化症患者表现出显着的反应性星形胶质细胞增生，内层视网膜中的 c3 表达比未受影响的眼睛更多地延伸到受影响的眼睛的更深层。

2023年10月3日 · 通过相关性分析发现c3的表达水平与多种免疫细胞相关（p<0.05）。在结节性硬化症患者脑组织和血浆中均发现补体c3升高，通过免疫荧光发现补体c3与gfap共定位。在星形胶质细胞系u87构建tsc2-ko细胞系模型发现补体c3升高。

First, we show extensive C3 expression in astrocytes (C3 + /GFAP + cells) and significant RGC loss (RBPMS + cells) in post-mortem retinas from people with MS compared to retinas from non-MS individuals. A patient with progressive MS with a remote history of optic neuritis showed marked reactive astrogliosis with C3 expression in the inner ...