微管结合蛋白 2 (MAP2) 是一种神经元磷蛋白，可调节微管的结构和稳定性、神经元形态形成、细胞骨架动力学以及轴突和树突细胞中的细胞器转运。

MAP2（微管相关蛋白2）是一种丰富的神经元细胞骨架蛋白，可与微管蛋白结合并稳定微管，在神经系统发育、形成和再生过程的不同时期扮演着重要的角色。

The single MAP2 gene produces four major transcripts producing four proteins, MAP2A, MAP2B, MAP2C and MAP2D. MAP2A and MAP2B are very high molecular weight proteins, with apparent molecular weight on SDS-PAGE about 250 kDa, while MAP2C and MAP2D are much lower molecular weight forms with apparent SDS-PAGE size about 70 kDa. [7]

2023年4月5日 · 1、 神经元树突标志物：微管相关蛋白Microtubule-associated protein-2 (MAP-2)：Neuron Dendrite-specific MAP; protein found specifically in dendritic branching of neuron 是组成神经元细胞骨架的重要组成成…

2023年5月31日 · Three microtubule-associated proteins (MAPs), MAP2, MAP4, and tau 4, 5, 6, 7, 8, which are the most well-studied mammalian-derived MAPs with similar primary structures, promote microtubule...

Three microtubule-associated proteins (MAPs), MAP2, MAP4, and tau 4 – 8, which are the most well-studied mammalian-derived MAPs with similar primary structures, promote microtubule polymerization and stabilize formed microtubules.

2017年5月2日 · Here we show that key proteins in the lectin arm of this pathway, MASP1, MASP2 and C3, are expressed in the developing cortex and that neuronal migration is impaired in knockout and knockdown...

2025年1月1日 · Molecular investigations revealed that inhibition of Toll-like receptor 2 (TLR2) or NF-κB reduced complement C3 expression in primary astrocytes following α-syn PFF treatment. Astrocyte-neuron communication via the C3/C3aR pathway influenced α-syn PFF-induced neuronal apoptosis and α-syn pathology, potentially through modulation of GSK3β.

检测成熟神经元时，可观察 MAP2 、 NeuN 、 神经丝-H 、 神经丝-L 和 神经丝-M 的表达。 多条证据表明，聚集蛋白或长期刺激会导致对细胞有害的慢性炎症，并引起阿尔茨海默病 (AD)、帕金森病 (PD) 和肌萎缩性脊髓侧索硬化症 (ALS) 等神经退行性疾病的发病。

2023年10月12日 · The membrane-bound complement inhibitor CD55 acts on the C3/C5 convertase level. Here, we fused MAP-2 to the four N-terminal domains of CD55 generating a targeted chimeric inhibitor to modulate complement activation at two different levels of the complement cascade.