It catalyzes the proteolytic cleavage of C3 into C3a and C3b, generated during activation through the classical pathway as well as the lectin pathway. C3a is an anaphylotoxin and the precursor …

2018年3月30日 · C3 被 C3 转化酶裂解成 C3a 和 C3b，前者是一种过敏毒素，能够引发补体介导的炎症反应；后者相反，是一种调理素，能够加强吞噬细胞的吞噬作用。 C3b 在 H因子和 I …

2005年9月22日 · Activation of component C3 (1,641 residues) is central to the three complement pathways and results in inflammation and elimination of self and non-self targets. Here we …

C3b 与细胞表面碳水化合物或免疫聚集体共价结合，而 C3a 作为炎症介质，诱导中性粒细胞趋化并促进平滑肌收缩、增加血管通透性和组胺释放。较短的 C3a 异构体可刺激 B 细胞 …

As the most abundant component of the complement system, C3 and its proteolytic derivatives serve essential roles in the function of all three complement pathways. Central to this is a …

2022年2月25日 · In this study, we examined the immunological properties of C3 and its activated fragment C3a from Japanese flounder (Paralichthys olivaceus) (PoC3 and PoC3a), a teleost …

prepared from (i) the C3c crystal structure and (ii) the C3 crystal structure with the domains lacking in C3c deleted (C3A). All 15 averages examined, including those from groups I, II, and …

C3a is a 77 residue anaphylatoxin that binds to the C3a receptor (C3aR), a class A G protein-coupled receptor. It plays a large role in the immune response. C3a molecules induce …

Complement component 3 (C3) is a key complement protein and its cleavage into C3a and C3b is central to all three complement pathways. Indeed, mice eyes develop many features of AMD …

2025年2月9日 · The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical …