It catalyzes the proteolytic cleavage of C3 into C3a and C3b, generated during activation through the classical pathway as well as the lectin pathway. C3a is an anaphylotoxin and the precursor of some cytokines such as ASP, and C3b serves as an opsonizing agent.

2018年3月30日 · C3 被 C3 转化酶裂解成 C3a 和 C3b，前者是一种过敏毒素，能够引发补体介导的炎症反应；后者相反，是一种调理素，能够加强吞噬细胞的吞噬作用。 C3b 在 H因子和 I 因子的作用下，也可以裂解成 iC3b，并进一步裂解为 C3dg 和 C3c，C3d 可能为 C3 裂解的最终片段。

2005年9月22日 · Activation of component C3 (1,641 residues) is central to the three complement pathways and results in inflammation and elimination of self and non-self targets. Here we present crystal structures...

C3b 与细胞表面碳水化合物或免疫聚集体共价结合，而 C3a 作为炎症介质，诱导中性粒细胞趋化并促进平滑肌收缩、增加血管通透性和组胺释放。较短的 C3a 异构体可刺激 B 细胞。Complement C3/C3a Protein, Mouse 是重组的 补充 C3/C3a 蛋白，由 E. coli 表达，不带标签。

As the most abundant component of the complement system, C3 and its proteolytic derivatives serve essential roles in the function of all three complement pathways. Central to this is a network of protein-protein interactions made possible by the sequential proteolysis and far-reaching structural changes that accompany C3 activation.

2022年2月25日 · In this study, we examined the immunological properties of C3 and its activated fragment C3a from Japanese flounder (Paralichthys olivaceus) (PoC3 and PoC3a), a teleost species with important economic value. PoC3 is composed of 1655 amino acid residues, contains the six domains and highly conserved GCGEQ sequence of the C3 family.

prepared from (i) the C3c crystal structure and (ii) the C3 crystal structure with the domains lacking in C3c deleted (C3A). All 15 averages examined, including those from groups I, II, and III, showed a higher correlation with C3c than C3A (Fig. 3 F-H and data not shown). This highly significant result (P = 2 x 2-15 =

C3a is a 77 residue anaphylatoxin that binds to the C3a receptor (C3aR), a class A G protein-coupled receptor. It plays a large role in the immune response. C3a molecules induce responses through the GPCR C3a receptor.

Complement component 3 (C3) is a key complement protein and its cleavage into C3a and C3b is central to all three complement pathways. Indeed, mice eyes develop many features of AMD when exposed to C3 administered via an adenovirus vector delivered by subretinal injection (Cashman et al. 2011a).

2025年2月9日 · The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients.