Expression of complement alternative pathway proteins by ... - PubMed
We have studied the secretion of proteins of the alternative pathway of complement C3, factor B and factor H by human umbilical vein endothelial cells (HUVEC). Results showed that factor H …
Hypoxia-induced expression of complement receptor type 1 …
1999年2月1日 · As the receptor for C3b is known to be present on injured bovine endothelial cells, we investigated whether hypoxia or inflammatory mediators induce complement receptor type …
Surface deposition and fragmentation of C3b on HUVEC
Factor H is a central regulator in plasma which protects host tissue from complement mediated damage. Here we characterize the relevance of surface attached factor H, and study the …
Reoxygenation of Hypoxic Human Umbilical Vein Endothelial …
1997年7月1日 · We investigated whether exposure of human umbilical vein endothelial cells (HUVECs) to hypoxia and/or reoxygenation activates complement and decreases HUVEC …
Assembly and Activation of Alternative Complement Components …
2013年3月29日 · We quantified gene expression of these complement components in cultured human umbilical vein endothelial cells (HUVECs) by real-time PCR: C3 and C5; complement …
Hyperfunctional C3 convertase leads to complement deposition …
2009年9月24日 · We demonstrated for the first time that factor B mutations lead to enhanced C3-fragment deposition on quiescent and adherent human glomerular cells (GEnCs) and human …
Complement C3 Deposition on Endothelial Cells Revealed by Flow ...
2021年4月14日 · Multiple endothelial cell types can be used: we usually use Human umbilical vein endothelial cells (HUVEC—a model of macrovascular EC) or Human dermal EC line …
The C-terminus of complement factor H is essential for host cell ...
2007年4月1日 · Here we characterize FH activity at the host cell surface in the presence of membrane-bound complement regulators, using human umbilical vein endothelial cells …
TNF-alpha stimulates the biosynthesis of complement C3 and
1997年6月3日 · The human umbilical cord vein (HUVEC) endothelial cells synthesize and secrete complement components. We analyzed the regulation of biosynthesis of the third component …
HUVEC take up opsonized zymosan particles and secrete …
2003年5月1日 · HUVEC took up more serum-opsonized than -unopsonized zymosan as demonstrated by flow cytometry with fluorescence-labeled particles. The former uptake was …