C3d is a fragment of the complement factor C3 and is generated in the course of complement activation. When bound to antigen in single or multiple copies, the B cell receptor and …

2020年8月24日 · Evaluation of C3b degradation products such as C3d can reveal an underlying FI defect. We measured C3d concentration in patients with CFI mutations or defects in other …

C3 is the central effector molecule of the complement system, mediating its multiple functions through different binding sites and their corresponding receptors. We will introduce the C3 …

By generating FI with an inactivated serine protease domain (S525A FI), a real-time surface plasmon resonance assay of C3b:FH:FI complex formation for characterising variants in CFH …

Structure determination of native C3, C3b and C3c has provided crucial insights into the mechanistic basis behind the activation of C3 to C3b (10, 11) while complexes of C3b with …

On the other hand, cofactor activity arises when RCA proteins bind C3b and facilitate recruitment of the degradative protease known as Complement Factor I (FI). Although the RCA proteins …

2024年4月3日 · C3d-mAb-2fH fusion proteins in this model inhibited glomerular complement and progression of renal injury without affecting systemic complement. These studies therefore …

2017年1月31日 · Meanwhile, erythrocyte CR1, in the presence of FI, mediates cleavage of C3b to iC3b and/or C3d, which is recognized by CR2 and CR3. The subcapsular sinus macrophages …

C3d is a fragment of the complement factor C3 and is generated in the course of complement activation. When bound to antigen in single or multiple copies, the B cell receptor and …

2020年5月5日 · Through iterative computational analysis and binding affinity experiments, we establish a rationale for the structure-based design of FH-inspired peptides, leading to low …