2024年11月5日 · C3 glomerulopathy (C3G) is a rare glomerular disease stemming from dysregulation of the complement system's alternative pathway, resulting in excessive C3 protein deposits in the kidney’s glomeruli.

2007年7月20日 · C3 glomerulopathy (C3G) is a complex ultra-rare complement-mediated renal disease caused by uncontrolled activation of the complement alternative pathway (AP) in the fluid phase (as opposed to cell surface) that is rarely inherited in a simple mendelian fashion.

2017年5月9日 · C3 glomerulopathy (C3G) is a rare set of kidney diseases with 2 patterns: C3 glomerulonephritis (C3GN) and dense deposit disease. Pathogenesis of both diseases is due to complement dysregulation in the alternative pathway. Acquired or genetic alterations of the regulatory proteins of the complement pathway result in C3G.

2014年8月12日 · To understand the cause of C3G, it's important to know about the complement system (the "C" in C3G). This system is a collection of proteins in the blood that, when functioning properly, help (complement) the immune system to fight invaders such as bacteria and viruses.

C3 glomerulopathy (C3G) is a rare set of kidney diseases with 2 patterns: C3 glomerulonephritis (C3GN) and dense deposit disease. Pathogenesis of both diseases is due to complement dysregulation in the alternative pathway. Acquired or genetic alterations of the regulatory proteins of the complement pathway result in C3G.

C3 glomerulopathy (C3G) describes a pathologic pattern of injury diagnosed by renal biopsy. It is characterized by the dominant deposition of the third component of complement (C3) in the renal glomerulus as resolved by immunofluorescence microscopy. The underlying pathophysiology is driven by dysre …

2023年9月6日 · C3 glomerulopathy (C3G) is diagnosed by kidney biopsy, with immunofluorescence showing isolated or dominant C3 staining, indicating hyperactivity of the alternative complement pathway as the key driver of glomerular injury. Therefore, the lesion is defined by its complement-mediated pathogenesis as much as its histological pattern.

2024年11月18日 · Complement inhibitors are becoming game changers in C3G and IC-MPGN. The optimal choice of drug may vary in individual subjects and conceivably, patients could be treated with different molecules during the induction and the maintenance phases. In this context, pegceptacoplan is a frontrunner in the race for the treatment of C3G and IC-MPGN.

Dysregulation of the alternative pathway of complement plays a central role in the pathophysiology of C3 Glomerulopathy (C3G). Various autoimmune and genetic factors targeting the alternative pathway have been associated to both C3G and primary Immunoglobulin-associated Membranoproliferative Glomeru …

2024年11月22日 · C3 glomerulopathy (C3G) is a rare and complex kidney disorder caused by the dysregulation of the immune system’s complement pathway, which plays a crucial role in defending the body against infections.