2005年9月22日 · Activation of component C3 (1,641 residues) is central to the three complement pathways and results in inflammation and elimination of self and non-self targets. Here we present crystal structures...

2020年4月9日 · TLQP-21 increases fAβ uptake by microglial BV2 cells via C3AR1-dependent mechanisms. TLQP-21 enhances the degradation of engulfed Aβ by stimulating a lysosomal degradation pathway.

2024年10月1日 · Highly accumulated C3a induces the aggregation and deposition of Aβ and tau. Activating axis of C3a-C3aR impairs the mitochondria through NLRP3 inflammasomes. NLRP3 inflammasomes-mediated activation of microglia results in synapse pruning.

2024年9月1日 · C3a, a potent anaphylatoxin, has been shown to exert protective effects in the brain, promoting neurogenesis and limiting neuroinflammation. Evidence suggests that disrupting C3a-C3aR signaling can alleviate cognitive decline in neurodegenerative diseases by shifting microglial phenotypes towards a more anti-inflammatory state.

2020年4月9日 · TLQP-21 also improved microglial phagocytic activity and promoted fibrillar amyloid-β (fAβ) uptake by microglial BV2 cells via a C3AR1-dependent mechanism. Moreover, TLQP-21 stimulated Aβ degradation by enhancing lysosome activity, thereby enhancing fAβ …

2017年12月12日 · Exogenous administration of recombinant CCL5 to C3aR-deficient mice rescues the defects in inflammatory cell recruitment and regeneration. These findings reveal an important role of complement C3a in skeletal muscle regeneration, and suggest that manipulating complement system may produce therapeutic benefit in muscle injury and regeneration.

2017年10月10日 · Although this novel C3a result is surprising, a recent paper has suggested that C3a and C3aR positively regulate axon growth-associated protein GAP43 as well as synapsin + and VGLUT1 + synaptic...

In this study, we examined the immunological properties of C3 and its activated fragment C3a from Japanese flounder (Paralichthys olivaceus) (PoC3 and PoC3a), a teleost species with important economic value. PoC3 is composed of 1655 amino acid residues, contains the six domains and highly conserved GCGEQ sequence of the C3 family.

补体系统是人体先天性免疫反应的重要组成部分，而 补体级联反应 （complement cascade）的最终产物---过敏毒素 C3a 和 C5a 在人体抵御有害入侵者的复杂过程中，补体系统发挥着关键作用。

The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients.