Insights into the Human CD59 Complement Binding Interface …
CD59 is a 77-amino acid membrane glycoprotein that plays an important role in regulating the terminal pathway of complement by inhibiting formation of the cytolytic membrane attack …
Structural basis for membrane attack complex inhibition by CD59
2023年2月16日 · CD59 is an abundant immuno-regulatory receptor that protects human cells from damage during complement activation. Here we show how the receptor binds complement …
CD59: Biological function and its potential for drug target action
2023年6月1日 · CD59 deficiency is associated with paroxysmal nocturnal hemoglobinuria (PNH). CD59 is implicated in cancer, autoimmune disorders, and diabetes mellitus. CD59 has …
WNT-C59, a Small-Molecule WNT Inhibitor, Efficiently Induces …
This article reports a novel differentiation method using a small-molecule WNT inhibitor, WNT-C59 (C59), to efficiently induce human anterior cortex. C59 efficiently induced CTIP2+/COUP-TF1− …
Wnt-C59 inhibits proinflammatory cytokine expression by …
2021年7月1日 · Wnt-C59 showed a dose-dependent anti-inflammatory effect by suppressing the expression of proinflammatory cytokines including IL6, CCL2, IL1A, IL1B, and TNF in LPS …
Wnt-Signaling Inhibitor Wnt-C59 Suppresses the Cytokine …
2021年6月10日 · Wnt-C59, which inhibits the palmitoylation and secretion of Wnt, has been developed as an anti-cancer drug candidate and shows anti-tumor activity in mouse models of …
WNT-C59，一种小分子WNT抑制剂，可有效诱导包括人类多能干 …
Here, we report a novel differentiation method using a small‐molecule WNT inhibitor, WNT‐C59 (C59), to efficiently induce human anterior cortex. We compared two types of small molecules, …
Wnt-C59, Wnt 拮抗剂, Wnt 信号通路抑制剂 - 知乎 - 知乎专栏
Wnt-C59 是一种 PORCN 的强效 抑制剂，通过阻止 Wnt3A 活化来测量 (IC50 = 74 pM)。 由于 Wnt 的分泌需要 棕榈酰化，Wnt-C59 完全阻断 Wnt3A 分泌到培养基中。 Wnt-C59 是一种 …
CD59 Antibody #65055 - Cell Signaling Technology (CST)
CD59 Antibody recognizes endogenous levels of total CD59 protein. Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues …
Wnt-C59 (C59) | PORCN 抑制剂 | MCE - MCE-生物活性分子大师
Wnt-C59 (C59) is a highly potent and oral porcupine (PORCN) inhibitor with an IC50 of 74 pM. Wnt-C59 (C59) inhibits PORCN activity in vitro at nanomolar concentrations, as assessed by …