2024年12月24日 · C5AR1 (Complement C5a Receptor 1) is a Protein Coding gene. Diseases associated with C5AR1 include Atypical Hemolytic-Uremic Syndrome and Hypersensitivity Reaction Type Iii Disease . Among its related pathways are Class A/1 (Rhodopsin-like receptors) and Complement cascade .

The C5a receptor also known as complement component 5a receptor 1 (C5AR1) or CD88 (Cluster of Differentiation 88) is a G protein-coupled receptor for C5a. It functions as a complement receptor. [5] C5a receptor 1 modulates inflammatory responses, obesity, development and cancers.

2022年6月1日 · 研究人员进一步使用C5和C5ar1基因敲除小鼠，构建了慢性结肠炎相关结肠癌（AOM/DSS-induced CAC model）和散发性结肠癌（ApcMinC-based sporadic CRC model）疾病模型，发现敲除C5或C5ar1可显著抑制肠道组织β-catenin的蛋白水平及激活，进而显著抑制结直 …

盐城市第一人民医院团队发现细胞内c5ar1通过mettl3介导的gpx4 m6a甲基化抑制胶质母细胞瘤铁死亡，促进其进展。 研究揭示C5aR1在GBM中的作用机制，包括与ERK1/2通路的关联等。

2023年2月17日 · Dysfunction of the C5a-C5aR1 axis is linked to numerous inflammatory and immune-mediated diseases, but the structural basis for activation and biased signaling of C5aR1 remains elusive.

C5aR1 is particularly relevant to sterile inflammation because activation of C5aR1 on endothelial cells during heightened complement activation induces an inflammatory state in these cells, whereas C5aR1 activation on innate immune cells fosters attachment to the inflamed endothelium, uptake of antigen, tissue infiltration, and induction of a ...

The complement fragment C5a is one of its important effector components and exerts diverse physiological functions through activation of the C5a receptor 1 (C5aR1) and associated downstream G protein and β-arrestin signaling pathways.

关于 c5ar1 Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:47,307,477-47,322,066 (from NCBI) This gene has 3 transcripts (splice variants), 161 orthologues and 8 paralogues.

2025年2月8日 · A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of complement component 5a receptor 1 (C5AR1) expression by HIV-1 Vpr in Vpr transduced macrophages: PubMed

作者发现当内皮细胞缺氧时，血小板可以在血管表达补体过敏毒素受体C5aR1。 而C5a介导的血小板的C5aR1的激活则抑制了对于血管形成十分重要的内皮细胞静态黏附、增殖、内皮管形成等功能。