PKCα integrates spatiotemporally distinct Ca - Nature
2018年7月16日 · Here, we develop highly sensitive, isozyme-specific sensors for each of the classical PKCs in order to analyze Ca 2+ -dependent PKC function in plasticity. We find that …
蛋白激酶C - 百度百科
PKC酶又被诸如二酰甘油（DAG）或钙离子（Ca2+）浓度增加的信号激活。 因此，PKC酶在几种信号转导级联中发挥重要作用。 在生物化学中，PKC家族由15种人类的同工酶组成。 根据其 …
Protein kinase C - Wikipedia
In cell biology, protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in controlling the function of other proteins through …
Protein kinase C-mediated calcium signaling as the basis for ...
2021年4月15日 · PKC blockade slightly increases [Ca 2+] in and NO levels, suppressing L-type currents. Receptor-mediated PKC activation modulates Ca 2+ release through ryanodine …
Activators and Inhibitors of Protein Kinase C (PKC): Their …
Protein kinase C (PKC), a family of phospholipid-dependent serine/threonine kinase, is classed into three subfamilies based on their structural and activation characteristics: conventional or …
Dynamics and membrane interactions of protein kinase C - PMC
Protein Kinase C (PKC) is a family of Ser/Thr kinases that regulate a multitude of cellular processes through participation in the phosphoinositide signaling pathway. Significant …
GPCR、钙、cAMP - Cell Signaling Technology (CST)
传统的 PKC 酶（cPKC；同工型 PKCα、PKCβ 和 PKCγ）包括功能性 C1 和 C2 调节结构域；要激活 cPKC 酶，需要将甘油二酯 (DAG) 和磷脂与 C1 结构域结合起来，同时将 Ca2+ 与 C2 结 …
蛋白激酶C - 维基百科，自由的百科全书
蛋白激酶C （英語： Protein kinase C，简称 PKC，EC编号：2.7.11.13）是一種 蛋白质 激酶 家族，通过将其它 蛋白质 的 丝氨酸 / 苏氨酸 侧链上的 羟基 磷酸化 来调节这些蛋白的活性。 而蛋 …
PKCα integrates spatiotemporally distinct Ca 2+ and autocrine …
The activation of PKCα during plasticity requires both NMDA receptor Ca 2+ flux and autocrine brain-derived neurotrophic factor (BDNF)-TrkB signaling, two pathways that differ vastly in …
PKC-α regulates cardiac contractility and propensity toward heart ...
2004年2月15日 · Here we identify PKC-α as a fundamental regulator of cardiac contractility and Ca 2+ handling in myocytes. Hearts of Prkca -deficient mice are hypercontractile, whereas …