2023年8月9日 · ARIA may be iatrogenic CAA-related inflammation. Anti-amyloid antibodies could trigger complement proteins to attack vascular amyloid. One TREM2 antibody causes ARIA as well. The hunt is on for biomarkers of CAA that could better predict ARIA risk.

CAA-RI consists of two subtypes: inflammatory cerebral amyloid angiopathy and amyloid β (Aβ)-related angiitis. Acute or subacute onset of cognitive decline or behavioral changes is the most common symptom of CAA-RI.

2023年6月6日 · Randomized clinical trials show reduced brain amyloid-β deposits using monoclonal antibodies that target amyloid-β and have identified MRI signal abnormalities called amyloid-related imaging abnormalities (ARIA) as possible spontaneous or treatment-related adverse events.

This study suggests that spontaneous ARIA-like as observed in CAA-ri may not be a rare inflammatory manifestation of the widely recognized and diffused Aβ-driven pathologies of aging.

2025年1月3日 · Two broad classes of mechanisms have emerged for understanding the Amyloid-Related Imaging Abnormalities (ARIA) associated with anti-beta-amyloid immunotherapy. One set of mechanisms proposes that ARIA is driven by large-scale transfer of antibody-bound amyloid from brain parenchyma to the perivascular and vascular compartments.

2024年3月28日 · In mice treated with anti-amyloid antibodies, MRI revealed human-like ARIA. The metalloprotease inhibitor TIMP4 could be a biomarker of CAA. Injections of ApoJ, aka clusterin, may help prevent microhemorrhages.

2021年9月16日 · This study suggests that spontaneous ARIA-like as observed in CAA-ri may not be a rare inflammatory manifestation of the widely recognized and diffused Aβ-driven pathologies of aging.

2023年1月12日 · Increased evidence suggests that drug-induced ARIAs are the iatrogenic manifestation of cerebral amyloid angiopathy–related inflammation (CAA-ri), a rare autoimmune encephalopathy associated with elevated CSF concentrations of spontaneous anti-Aβ autoantibodies (autoAbs) and transient focal areas of swelling (also known as ARIA-E in …

WHAT IS ARIA? WHAT ARE THE SYMPTOMS OF ARIA? Amyloid-related imaging abnormalities, also known as ‘ARIA’, are a consequence of the presence of amyloid in blood vessel walls (cerebral amyloid angiopathy [CAA]).1 CAA can cause spontaneous ARIA in patients with Alzheimer’s disease (AD)1 The risk of ARIA is increased with the use of monoclonal

ARIA is a consequence of the presence of amyloid in cerebral blood vessel walls (cerebral amyloid angiopathy [CAA]), which can cause spontaneous ARIA in patients with AD.1 The increased occurrence of ARIA-E seen with treatments that remove amyloid plaques is thought to be due to the removal of