2021年6月10日 · CAFs are highly heterogeneous stromal cells and their crosstalk with cancer cells is mediated by a complex and intricate signaling network consisting of transforming growth factor-beta,...

2017年11月1日 · Originally characterized as angiogenic factors, fibroblast growth factors (FGFs) are pleiotropic factors that exert autocrine and paracrine functions on tumor and stromal cells. Thus, they may represent key players in the complex crosstalk among angiogenesis, inflammation, tumor growth, and drug resistance, all contributing to tumor progression.

2023年7月3日 · Cancer-associated fibroblasts (CAFs), as a central component of the tumor microenvironment in primary and metastatic tumors, profoundly influence the behavior of...

2021年2月6日 · To determine the functional role of TGF-β1, we treated normal gastric fibroblasts (GFs) with recombinant TGF-β1, which caused the GFs to adopt a more stellate morphology, as well as increased the...

2021年11月1日 · TGF-β in CAFs significantly contributes to cancer drug resistance. Targeting the TGF-β signaling can have a therapeutic benefit in successful cancer management. Over the last few years, the Transforming growth factor- β (TGF-β) has been significantly considered as an effective and ubiquitous mediator of cell growth.

2023年12月20日 · In recent years, research focused on the multifaceted landscape and functions of cancer-associated fibroblasts (CAFs) aimed to reveal their heterogeneity and identify commonalities across diverse tumors for more effective therapeutic targeting of pro-tumoral stromal microenvironment.

2019年8月27日 · Heterogeneity of cancer-associated fibroblasts (CAFs) can result from activation of distinct signaling pathways. We show that in primary human dermal fibroblasts (HDFs), fibroblast growth factor (FGF) and transforming growth factor β (TGF-β) signaling oppositely modulate multiple CAF effector genes.

FGF19 mediates the polarization of hepatic stellate cells to inflammatory cancer-associated fibroblasts (iCAFs) by activating the autocrine effect of IL-1 α via the FGFR4-JAK2-STAT3 pathway.

针对CAFs及其相关分子的免疫治疗主要有以下三种方法：A. 通过针对FAP、α-SMA和PDGFR等CAFs标志物的免疫疗法或转基因技术，可以直接消耗CAFs，从而增强TME中的免疫反应；B. 通过抑制其关键效应分子或信号通路（如维生素A、TGF-β、IL-6以及JAK-STAT3信号通路、CCR2信号轴等），抑制CAFs的激活和功能，从而抑制TME中CAFs诱导的免疫抑制；C. CAFs衍生的基质蛋白（如TNC、HA、MMPs）以及相关的纤维化激活信号通路（如FAK信号通路）是有效限 …

Within the TME, cancer-associated fibroblasts (CAFs) have been identified in several systemic cancers as critical regulators of the malignant cancer phenotype. This review of the literature comprehensively profiles the roles of CAFs implicated in gastrointestinal, endocrine, head and neck, skin, genitourinary, lung, and breast cancers.