Signaling pathways in cancer-associated fibroblasts and targeted ...
2021年6月10日 · CAFs are highly heterogeneous stromal cells and their crosstalk with cancer cells is mediated by a complex and intricate signaling network consisting of transforming …
Fibroblast growth factors (FGFs) in cancer: FGF traps as a new ...
2017年11月1日 · Originally characterized as angiogenic factors, fibroblast growth factors (FGFs) are pleiotropic factors that exert autocrine and paracrine functions on tumor and stromal cells. …
Cancer-associated fibroblasts: from basic science to ... - Nature
2023年7月3日 · Cancer-associated fibroblasts (CAFs), as a central component of the tumor microenvironment in primary and metastatic tumors, profoundly influence the behavior of...
TGF-β1-mediated transition of resident fibroblasts to cancer
2021年2月6日 · To determine the functional role of TGF-β1, we treated normal gastric fibroblasts (GFs) with recombinant TGF-β1, which caused the GFs to adopt a more stellate morphology, …
The transformation of cancer-associated fibroblasts: Current ...
2021年11月1日 · TGF-β in CAFs significantly contributes to cancer drug resistance. Targeting the TGF-β signaling can have a therapeutic benefit in successful cancer management. Over the …
Transcription factors in fibroblast plasticity and CAF heterogeneity ...
2023年12月20日 · In recent years, research focused on the multifaceted landscape and functions of cancer-associated fibroblasts (CAFs) aimed to reveal their heterogeneity and identify …
Dualism of FGF and TGF-β Signaling in Heterogeneous Cancer …
2019年8月27日 · Heterogeneity of cancer-associated fibroblasts (CAFs) can result from activation of distinct signaling pathways. We show that in primary human dermal fibroblasts (HDFs), …
FGF19‐Induced Inflammatory CAF Promoted ... - Wiley Online Library
FGF19 mediates the polarization of hepatic stellate cells to inflammatory cancer-associated fibroblasts (iCAFs) by activating the autocrine effect of IL-1 α via the FGFR4-JAK2-STAT3 …
Mol Cancer|复旦大学施思团队就肿瘤微环境中CAFs和免疫细胞之 …
针对CAFs及其相关分子的免疫治疗主要有以下三种方法：A. 通过针对FAP、α-SMA和PDGFR等CAFs标志物的免疫疗法或转基因技术，可以直接消耗CAFs，从而增强TME中的免疫反应；B. …
The Role of Cancer-Associated Fibroblasts in Tumor Progression
Within the TME, cancer-associated fibroblasts (CAFs) have been identified in several systemic cancers as critical regulators of the malignant cancer phenotype. This review of the literature …