CARM1 (coactivator-associated arginine methyltransferase 1), also known as PRMT4 (protein arginine N-methyltransferase 4), is an enzyme (EC 2.1.1.125) encoded by the CARM1 gene found in human beings, as well as many other mammals. [2] It has a polypeptide (L) chain type that is 348 residues long, and is made up of alpha helices and beta sheets. [3]

2024年12月24日 · CARM1 (Coactivator Associated Arginine Methyltransferase 1) is a Protein Coding gene. Diseases associated with CARM1 include Hematologic Cancer and Encephalopathy, Neonatal Severe, Due To Mecp2 Mutations. Among its related pathways are Transcriptional regulation of white adipocyte differentiation and Circadian Clock.

2024年10月，中国医学科学院和首都医科大学基础医学院团队联合在Protein Cell（IF=13.6）上发表了题为“CARM1 drives triple-negative breast cancer progression by coordinating with HIF1A”的研究成果。 揭示CARM1在TNBC中癌变的分子基础及其有效的天然抑制剂，可能为癌症治疗提供新的思路和药物。 图形摘要： Highlights如下： 1）CARM1在乳腺癌样本中高表达，与组织学分级呈正相关； 2）CARM1促进TNBC进展； 3）CARM1与HIF1A协同促进TNBC的进展；

该酶特异性作用于组蛋白和其他染色质相关蛋白，并参与基因表达的调节。 该酶可能与其他蛋白质联合作用或在多蛋白质复合物中起作用，并可能在细胞类型特异性功能和细胞谱系规范中发挥作用。 一个相关的假基因位于 9 号染色体上。 [RefSeq 提供，2013 年 8 月] This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded Enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins.

2022年11月5日 · 作者从肿瘤特异性T细胞中出发，用CRISPR/Cas9技术筛选抗肿瘤免疫的负调节因子，发现了一个名为Carm1的基因，体外敲除T细胞中的Carm1基因能够增强T细胞对黑色素瘤细胞B16F10-Ova的杀伤力。

We discovered that inhibition of CARM1, an epigenetic enzyme and cotranscriptional activator, elicited beneficial antitumor activity in both cytotoxic T cells and tumor cells. In T cells, Carm1 inactivation substantially enhanced their antitumor function and preserved memory-like populations required for sustained antitumor immunity.

Coactivator-associated arginine methyltransferase 1 (CARM1), identified 20 years ago as a coregulator of transcription, is an enzyme that catalyzes arginine methylation of proteins. Beyond its well-established involvement in the regulation of transcription, the physiological functions of CARM1 are s …

2024年4月24日 · We analyzed the level of different types of alternative splicing events of Carm1 pre-mRNAs, including exon-skipping, retained introns, alternative 5′-splicing site, alternative 3′-splicing site,...

共激活蛋白相关的精氨酸甲基转移酶1 (coactivator-associated arginine methyltransferase 1, CARM1)是蛋白质精氨酸甲基转移酶(protein arginine methyltransferase, PRMT)家族的成员, 又称PRMT4。近年来, CARM1作为一种辅助转录调节因子已被广泛研究, 并被发现在肿瘤、炎性疾病、 …

2017年5月24日 · PRMT4 or coactivator-associated arginine methyltransferase 1 (CARM1) is a propitious target for cancer therapy; however, few CARM1 substrates are known, and its mechanism of substrate recognition...