2024年12月24日 · CASP1 (Caspase 1) is a Protein Coding gene. Diseases associated with CASP1 include Cowpox and Shigellosis. Among its related pathways are Inflammasomes and Gene expression (Transcription). Gene Ontology (GO) annotations related to this gene include peptidase activity and cysteine-type peptidase activity. An important paralog of this gene is …

Caspase-1 Zymogen. Caspase-1/Interleukin-1 converting enzyme (ICE) is an evolutionarily conserved enzyme that proteolytically cleaves other proteins, such as the precursors of the inflammatory cytokines interleukin 1β and interleukin 18 as well as the pyroptosis inducer Gasdermin D, into active mature peptides. [5] [6] [7] It plays a central role in cell immunity as …

半胱天冬酶 1： 该基因编码的蛋白质是半胱氨酸-天冬氨酸蛋白酶 (半胱天冬酶) 家族的成员。半胱天冬酶的顺序激活在细胞凋亡的执行阶段起着核心作用。半胱天冬酶作为无活性的酶原存在，在保守的天冬氨酸残基上进行蛋白水解加工，产生大小不一的 2 个亚基，这些亚基二聚化形成活性酶。 …

2025年2月9日 · Title: Testis cell pyroptosis mediated by CASP1 and CASP4: possible sertoli cell-only syndrome pathogenesis. Overexpression of CASP1 triggers acute promyelocytic leukemia cell pyroptosis and differentiation.

2017年3月27日 · To investigate the contribution of caspase-1 in LPS endotoxemia in Casp1 Null mouse strain, we injected LPS into WT, Casp1 Null, Casp1 −/− Casp11 −/− and Casp11 −/− mice and monitored ...

2025年2月9日 · The NLRP3-CASP1 inflammasome modulates cellular levels of the glucocorticoid receptor and diminishes cell sensitivity to glucocorticoids. The relative level of aortic caspase-1 expression was elevated in patients who were smokers or with hypertension or diabetes.

作用于多个过程的上游或内部，包括膜超极化；线粒体去极化；和 IL-1 α 产生的正向调节。位于胞外区。 IPAF 炎性复合体的一部分。表达于膝关节和后肾。与人类 CASP1（caspase 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

CASP1 and CASP5 are activated when they assemble with NALP1 and ASC to form the inflammasome, which is responsible for processing the inactive IL1B precursor (proIL1B) to release active IL1B cytokine.

这个基因编码一个属于半胱氨酸-天冬氨酸蛋白酶(caspase)家族的蛋白质。caspases的序列激活在细胞凋亡的执行阶段起着核心作用。caspases以不活跃的前酶形式存在，在保守的天冬氨酸残基处经过蛋白水解加工，产生两个亚基，大亚基和小亚基，它们二聚形成活性酶。

位于细胞质中；神经元投射；和核。部分含蛋白质复合物。用于研究急性肾功能衰竭和视觉性癫痫。与人类 CASP1（caspase 1）同源。 [由基因组资源联盟提供，2022 年 4 月] Enables scaffold protein binding activity.