Suppression of peripheral NGF attenuates neuropathic pain …
2020年4月20日 · Perisciatic nerve administration of l-CDL suppressed the expression of NGF in the DRG and sciatic nerve of CCI rats. NGF plays a vital role in neuropathic pain, and the high …
NGF antibodies and small-molecule inhibitors of NGF or the related receptors have been developed for the treatment of neuropathic pain. This review summarized the mechanisms of …
触液核NGF/ERK信号通路参与CCI大鼠神经病理性疼痛
CCI大鼠术后第6天在立体定位仪下侧脑室分别注射NGF抗体、PBS及对照抗体,测定MWT和TWL后处死并取触液核进行Western Blot观察p-ERK的表达变化情况。...
Effect of NGF and anti-NGF on neuropathic pain in rats following ...
1999年2月1日 · In our study, we looked at the effects to the ligated nerves after 30 consecutive days of local injections of anti-NGF and NGF. A high-dose of anti-NGF (1800 ng) was found to …
Suppression of peripheral NGF attenuates neuropathic pain ... - PubMed
2020年4月20日 · In CCI rats, macropahages and Schwann cells could secret NGF to act on the receptors in the periphery to activate TAK1-MAPK/NF-κB axis and promote the release of …
神经病理性疼痛中神经生长因子的作用及其相关镇痛药物研发进展_ …
在坐骨神经慢性压迫损伤（chronic instruction injury，CCI） [1]、脊神经结扎（spinal nerve ligation，SNL） [2]、紫杉醇 [3]等诱导的神经病理性疼痛动物模型中NGF蛋白水平异常升高， …
Effect of NGF and anti-NGF on neuropathic pain in rats following ...
The systemic administration of anti-nerve growth factor (NGF) antibodies can prevent local sensory hypersensitivity and block nociceptive fibers from sprouting into denervated adult rat …
Anti-NGF treatment can reduce chronic neuropathic pain by …
We examined the effectiveness of anti-NGF in reducing chronic pain by local administration in a rat model of sciatic constriction injury (CCI). NGF and substance P in the dorsal root ganglion …
触液核NGF/ERK信号通路参与CCI大鼠神经病理性疼痛
2020年9月27日 · 摘要： 目的:观察神经生长因子(nerve growth factor,NGF)在坐骨神经慢性压迫性损伤(chronic con-striction injury,CCI)大鼠触液核的表达以及拮抗触液核NGF对CCI大鼠痛行为 …
Suppression of peripheral NGF attenuates neuropathic pain …
2020年4月20日 · Perisciatic nerve administration of l-CDL suppressed the expression of NGF in the DRG and sciatic nerve of CCI rats. NGF plays a vital role in neuropathic pain, and the high …