Chemokine (C-C motif) ligand 1 (CCL1) is also known as small inducible cytokine A1 and I-309 in humans. CCL1 is a small glycoprotein that belongs to the CC chemokine family. CCL1 is encoded by CCL1 gene which is one of the several chemokine genes clustered on the chromosome 17q11.2-q12 in humans. [1] .

CCL1 is an antimicrobial protein with bacteriocidal activity against E. coli and S. aureus. These data identify a novel function for CCL1-CCR8 in metastasis and lymph node LECs as a critical checkpoint for the entry of metastases into the lymph nodes. CCL1, CCL26, and IgE may be associated with pruritus in cutaneous T-cell lymphoma.

2024年12月24日 · CCL1 (C-C Motif Chemokine Ligand 1) is a Protein Coding gene. Diseases associated with CCL1 include Kaposi Sarcoma and Mast-Cell Leukemia. Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include cytokine activity and chemokine activity.

Chemokine (C-C motif) ligand 1 (CCL1) is produced by activated monocytes/ macrophages and T-lymphocytes, and acts as a potent attractant for Th2 cells and a subset of T-regulatory (Treg) cells. Previous reports have indicated that CCL1 is overexpressed in adult T-cell leukemia cells, mediating an autocrine anti-apoptotic loop.

Liu et al. (2021) found that the expression of CCL1 is upregulated in lung tissues of PF patients and mice. CCL1 exerts its fibrogenic activity by signaling through autocrine motility factor receptor (AMFR) on lung fibroblasts and activating those cells into pathological myofibroblasts.

2011年11月4日 · CCL1 transcription was increased in primary human CD4 + T cells abundantly expressing TIM-3 but not in cells with low expression of TIM-3. CCL1 was identified as a differentially transcribed gene in TIM-3-expressing CD4 + T cells. Keywords: TIM-3, Gene expression, CD4+ T cell, CCL1.

2018年12月20日 · We found a high expression of CCL1 in human breast cancer. CCL1 significantly correlated with the infiltration of immunosuppressive FoxP3+ Treg, that are known to negatively affect survival. Thus, CCL1 may serve as prognostic marker and novel therapeutic target in breast cancer.

2010年6月15日 · Chemokine (C-C motif) ligand 1 (CCL1) was highly differentially regulated in Tregs in the presence of IL-6, and its neutralization both inhibited Treg conversion and suppressive function. However, anti-CCL1 did not affect T effector viability or proliferation.

2011年2月7日 · CCL1, Chemokine (C-C motif) ligand 1, which is also known as I-309 or small inducible cytokine A1, is a monocyte chemoattractant protein of the CCL family. You might find these chapters and articles relevant to this topic. Bernhard Homey …

2021年9月14日 · Chemokine (C-C motif) ligand 1 (CCL1) regulates tissue homeostasis through the recruitment of immune cells to sites of injury and inflammatory tissues through its interaction with its receptor, CCR8 (Gombert et al., 2005; Knipfer et al., 2019).