CCL11 is a small cytokine belonging to the CC chemokine family. CCL11 selectively recruits eosinophils by inducing their chemotaxis, and therefore, is implicated in allergic responses. [7][8][9] The effects of CCL11 are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor.

趋化因子-11（CCL11）又称为嗜酸性粒细胞趋化因子（Eotaxin），属于CC趋化因子中单核细胞趋化蛋白成员。 CCL11对 嗜酸性粒细胞、嗜碱性粒细胞和Th2淋巴细胞具有很强的趋化作用。 Th2细胞因子，如IL-4、IL-10、IL-13、补体因子和免疫复合物，可诱导嗜酸性粒细胞、T细胞、B细胞、巨噬细胞、内皮细胞、成纤维细胞、上皮细胞、软骨细胞、小胶质细胞、角质形成细胞和平滑肌细胞产生CCL11。 CCL11基因在多种组织中表达，包括心、肺、肾、淋巴结、胸腺和肠道。 …

2024年12月24日 · CCL11 (C-C Motif Chemokine Ligand 11) is a Protein Coding gene. Diseases associated with CCL11 include Asthma and Human Immunodeficiency Virus Type 1. Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include chemokine activity.

CCL11, also known as eosinophil chemotactic protein, eotaxin-1, is a small cytokine of the CC chemokine family and in humans is a protein encoded by the CCL11 gene on chromosome 17. CCL11 is constitutively expressed in a variety of tissues including the intestine, lymph nodes, thymus, skin, heart, kidney and breast.

Chronic inflammation involves CCL11 and IL-13 to facilitate the development of liver cirrhosis and fibrosis in chronic hepatitis B virus infection. Chemoattraction of Neoplastic Glial Cells with CXCL10, CCL2 and CCL11 as a Paradigm for a Promising Therapeutic Approach for …

CCL11, also referred to as eotaxin1, acts as a chemoattractant for eosinophils. Two other members of the eotaxin family, have also been identified: CCL24 (eotaxin2) and CCL26 (eotaxin3). They are important in Th2 cell responses and …

2023年7月1日 · 趋化因子配体11 (CCL11)也称为 嗜酸性粒细胞 趋化因子 (Eotaxin)，是CC趋化因子家族中的小分子量细胞因子 [5]。 大部分与 CCL11 相关的研究都集中在它作为嗜酸性粒细胞转运的调节因子的作用，相比之下，CCL11 的嗜酸性粒细胞非依赖性作用几乎没有得到充分研究。 根据Berkman 等人的一项研究表明，CCL11 可以在体外直接增强人肺成纤维细胞的 ECM 生成和微观增殖能力，这一过程类似于 HSC-肌成纤维细胞转变 [6]， 这一研究结果促使研究者提出假 …

CCL11 levels in blood, EBC and sputum were significantly higher in asthma patients than in healthy subjects. Sputum CCL11 concentrations were significantly elevated in unstable asthma patients versus stable asthma patients and in uncontrolled asthma patients versus partially controlled asthma patients.

2023年10月4日 · Introduction: Eotaxin-1/CCL11 is a pivotal chemokine crucial for eosinophil homing to the lungs of asthmatic patients. Recent studies also suggest that CCL11 is involved in the aging process, as it is upregulated in elderly, and correlated with shorter telomere length in leukocytes from asthmatic children.

2023年9月7日 · 哮喘是一种气道炎症性疾病，特征是气道嗜酸性细胞增多，并且CCL11（嗜酸性细胞趋化因子）在其中起着至关重要的作用。 哮喘患者的血液、呼气气溶液（EBC）和痰液中的CCL11水平明显高于健康人。 与稳定状态的哮喘患者相比，痰液中的CCL11浓度在不稳定状态的哮喘患者中明显升高，而与得到部分缓解的哮喘患者相比，在未缓解哮喘患者中进一步升高。 同样，CCL11浓度与EBC、血液和痰液中的嗜酸性蛋白以及痰液中的白细胞介素-5和呼气一氧化氮 …