2022年3月30日 · Chemokine C-C motif ligand 2 (CCL2), also termed monocyte chemoattractant protein 1, is known as a pivotal chemoattractant for immune-cells, especially monocytes and T-cells, and is involved in pathogenesis of a number of diseases [1, 2, 3, 4].

2025年3月5日 · We explored this issue using healthy and simian immunodeficiency virus (SIV) infected monkeys and found: 1) Neurons were a major source of CCL2-like immunoreactivity (CCL2-ir) in normal GM, and corpus callosum (CC) ependyma showed high density of CCL2-ir. 2) Upon SIV infection, CCL2-ir was strikingly raised in GM neurons, and in CC ependyma.

We explored this issue using healthy and simian immunodeficiency virus (SIV) infected monkeys and found: 1) Neurons were a major source of CCL2-like immunoreactivity (CCL2-ir) in normal GM, and corpus callosum (CC) ependyma showed high density of CCL2-ir. 2) Upon SIV infection, CCL2-ir was strikingly raised in GM neurons, and in CC ependyma. 3 ...

2024年5月14日 · 越来越多的研究表明：CCL2通过CCR2作用于靶细胞维持了肿瘤细胞的生长和增殖；CCL2能够招募CCR2+TAM、MDSCs和Th2细胞，创造一个促进肿瘤进展的免疫抑制微环境；此外，TAM分泌的血管内皮生长因子 (VEGF)通过与CCR2+血管内皮细胞相互作用促进肿瘤血管生成；在次要部位，CCL2促进单核细胞向M2的极化和转移肿瘤前生态位的形成，加速转移性肿瘤细胞的定植和生长。

Our electron microscopy studies revealed that neuronal CCL2-IR was sorted to presynaptic SCV and DCV in glomerular boutons. Furthermore, CCL2-IR was detected along the microtubule network of unmyelinated and thinly myelinated axons, strongly suggesting that CCL2, like SP and CGRP, is transported from DRG neurons to central axon terminals.

Chemokine (C-C motif) ligand 2 (CCL2), also known as monocyte chemoattractant protein-1 (MCP-1), is a member of the β or C-C family of chemokines and is a ligand for chemokine receptor 2 (CCR2). 4, 5 For a long time, inflammatory CCL2 was thought to be involved specifically in the hematological system and in immune responses. 6 Although it is al...

ccl2与ccr2相互作用，维持肿瘤细胞生长和增殖；ccl2可招募ccr2+tams、mdscs和th2细胞，创造利于肿瘤进展的免疫抑制微环境；tam分泌的vegf通过与ccr2+血管内皮细胞的相互作用促进肿瘤血管生成；ccl2促进单核细胞分化为mams以及肿瘤转移前生态位的形成，加速转移性肿瘤 ...

The CCL2 polymorphism was associated with IR (polymorphic A+ phenotype frequencies were 70.9%, 82.6%, in individuals with and without IR, resp.). Phenotype carriers CCL2 (A+) displayed lower body mass and fat indexes, insulin and HOMA-IR, and higher adiponectin levels. Individuals with IR presented higher sCCL2 compared to individuals without ...

2022年3月30日 · Results: (1) CCL2 like immunoreactivity (CCL2-ir) in the CC is evidently higher than the cortex. When the measurement includes ependymal layer attached to the CC, CCL2-ir intensity is significantly higher than cortex.

2024年6月1日 · CCL2 is constitutively expressed during homeostatic functions such as monocytes mobilization and lymphocytes trafficking, while during pathological conditions such as chronic inflammation (e.g. in cancer), CCL2 axis promotes attraction of CCR2-expressing cells such as TAMs, myeloid cells, Tregs and cancer cells, cancer cell invasion and ...