趋化因子2 (CCL2) - 知乎 - 知乎专栏
2024年5月14日 · 趋化因子 (chemokine)是能够趋化细胞定向移动的小分子细胞因子,自1988年ValenteAJ等发现第一个趋化因子CCL2 (MCP21)以来,趋化因子及其受体的结构、功能及在体 …
The role of MCP-1 (CCL2) and CCR2 in multiple sclerosis and ...
2003年2月1日 · Using immunocytochemistry and in situ hybridization, CCL2 expression has been demonstrated within active and chronic active lesions in MS. Hypertrophic astrocytes and, to a …
CCL2/MCP-1在其相关疾病的机制研究 - 仁和软件
CCL2是趋化因子CC亚家族 (又称β亚家族)成员之一，即单核细胞趋化蛋白-1 (monocyte chemotactic protein-1，MCP-1)，可以趋化单核细胞、巨噬细胞和T淋巴细胞，影响其吞噬作用 …
趋化因子CCL2/MCP-1 - 知乎 - 知乎专栏
研究表明，CCL2促进破骨细胞前体细胞的迁移，促进破骨细胞的发生和骨吸收。 CCL2和CCR2基因变异是 骨质疏松症 的危险因素。 CCL2在骨质疏松性骨和前列腺癌引起的骨吸收中有广泛 …
The role of MCP-1 (CCL2) and CCR2 in multiple sclerosis and ...
Expression and cellular localization of CCL2/MCP-1 and CCR2 in MS have been described in the three compartments: brain, cerebrospinal fluid (CSF) and blood. Evidence from descriptive, …
A comprehensive review on the role of chemokines in the …
2021年1月6日 · Inflammatory chemokines that act as chemoattractants for monocytes and T cells have been shown to contribute in the pathogenesis of MS. Levels of these chemokines have …
The Role of Chemokines (CCL2, CCL5 and CXCL10) in the
2023年12月1日 · The concentration of CCL2, CLL5, and CXCL10 are elevated in MS, and increase more with longer disease duration. Thus, the level of chemokines and any mutation in …
Role of chemokine CCL2 and its receptor CCR2 in ... - Springer
2013年6月15日 · Chemokine CCL2, a member of the monocyte chemoattractant protein (MCP) family, and its receptor CCR2 have been implicated in many neurodegenerative disorders. …
Chemokine CCL2 and chemokine receptor CCR2 in early active …
The chemokine monocyte chemoattractant protein (MCP)-1/CCL2 and its receptor CCR2 have been strongly implicated in disease pathogenesis in experimental autoimmune …
The levels of chemokines CXCL8, CCL2 and CCL5 in multiple
Chemokines are small cytokines with selective chemoattractant properties. They contribute to the T-cell-mediated pathogenesis of multiple sclerosis (MS). In order to ascertain whether different …