2020年2月14日 · Mesenchymal stromal cells (MSC) have immunomodulatory effects impacting macrophages, promoting polarisation towards a reparative phenotype. CCL2 is a potent cytokine involved in the recruitment...

We identify that BM-MSC-secreted chemokine ligand 2 (CCL2) and C-X-C motif chemokine 12 (CXCL12) cooperate as a heterodimer to upregulate IL-10 expression in CCR2 + macrophages in vitro and that CCL2 expression by MSC is required for IL-10 + polarization of intestinal and peritoneal resident macrophages in vivo.

2020年2月11日 · We identify that BM-MSC-secreted chemokine ligand 2 (CCL2) and C-X-C motif chemokine 12 (CXCL12) cooperate as a heterodimer to upregulate IL-10 expression in CCR2 + macrophages in vitro and that CCL2 expression by MSC is required for IL-10 + polarization of intestinal and peritoneal resident macrophages in vivo. We observe that tissue ...

2021年9月13日 · 7月，北大医院血液内科任汉云教授、李渊副教授团队研究发现骨髓来源间充质干细胞（Mesenchymal stem cells，MSCs）可通过调节趋化因子CCR2-CCL2轴抑制T细胞活化，诱导具有免疫调节作用的CCR2+CD4+T细胞生成，进而达到预防小鼠异基因造血干细胞移植后特发 …

2021年4月20日 · In SLE patients, decreased expression of CCL2 on mesenchymal stem cells (MSC) prevents inhibition of B-cell proliferation, causing the characteristic autoimmune phenotype. Nevertheless, the...

2024年3月12日 · Single-cell RNA sequence analysis in human bone marrow cells confirms the significance of MSC-derived CCL2 in cell fate determination, providing valuable insights on the in vivo effects of MSC transplantation.

2020年2月14日 · Mesenchymal stromal cells (MSC) have immunomodulatory effects impacting macrophages, promoting polarisation towards a reparative phenotype. CCL2 is a potent cytokine involved in the recruitment of macrophages. We hypothesised that MSC derived CCL2 may be involved in the MSC therapeutic effect by fac …

2022年11月26日 · We found that MSCs-IT significantly alleviated skin fibrosis during SSc by reducing the infiltration of pathogenic CCR2 hi macrophages. MSC-IT treatment reduced the generation of CCL2 from...

2008年12月15日 · We demonstrate that the secretome of mesenchymal stromal cells (MSCs) suppresses plasma cell (PC) immunoglobulin (Ig) production, induces plasmablast proliferation, and leads to interleukin-10–mediated blockade in vitro. We found that these effects are the result of MSC-derived CC chemokine ligands CCL2 and CCL7.

The contribution of MSC‐borne chemokines, CCL2 in particular, and the recently recognized biological role of CC/CXC chemokine heterodimers found in MSC secretome as potent agents of immune modulation provide novel insights in identifying MSC cellular attributes predictive of clinical response.