The isoenzyme of glutaminyl cyclase is an important regulator of ...
2011年7月20日 · Genetic ablation of the glutaminyl cyclase iso‐enzymes QC (QPCT) or isoQC (QPCTL) revealed a major role of isoQC for pE 1 ‐CCL2 formation and monocyte infiltration. …
Functions of glutaminyl cyclase and its isoform in diseases
The expression of QC/isoQC is upregulated by proinflammatory cytokines such as CCL2 and CX3C chemokine ligand 1 (CX3CL1), which act as its substrates. CCL2 is a chemokine known …
Therapeutic potential of glutaminyl cyclases: Current status and ...
2023年10月1日 · In addition, the pE-modification of C-C motif chemokine ligand (CCL)-2 by QPCTL will also upregulate local CCL2 expression, which might, in turn, induce …
Glutaminyl cyclases, the potential targets of cancer and ...
2022年9月15日 · QC inhibitor SEN177 could block the interaction of CD47-SIRPα axis. sQC promotes the stability of HRAS and reduces its ubiquitination-mediated degradation, leading to …
Cell Prolif|华西医院魏霞蔚团队对CCL2-CCR2信号轴在癌症中作用 …
在本文中，团队总结了CCL2-CCR2信号轴在肿瘤发生发展中的作用，并重点介绍了其靶向治疗肿瘤的最新研究，尤其针对临床前研究和临床试验。 趋化因子是小分子蛋白，其通过与细胞表 …
Discovery of potential scaffolds for glutaminyl cyclase inhibitors ...
2024年1月1日 · The presence of pE considerably prolongs the in vivo half-life of CCL2 and enhances the recognition and binding of CCL2 and CCL2 receptor, causing excessive …
Glutaminyl Cyclase, Diseases, and Development of Glutaminyl …
2021年5月17日 · This upregulation catalyzes the generation of modified mediators such as pE-amyloid beta (Aß) and pE-chemokine ligand 2 (CCL2) peptides. Not surprisingly, QC has …
Focal Cerebral Ischemia Induces Expression of Glutaminyl
2024年8月23日 · In parallel, immunohistochemical signals for the QC substrate CCL2 increased from 24 to 72 h after ischemia induction without differences between genotypes analyzed. The …
Inhibition of Glutaminyl Cyclases alleviates CCL2-mediated ... - PubMed
Application of a QC/isoQC inhibitor led to a significant reduction in circulating alanine aminotransferase and NAFLD activity score accompanied by an inhibitory effect on hepatocyte …
Chronic treatment with the (iso-)glutaminyl cyclase ... - Springer
2021年3月29日 · The N-terminal glutamine on immature CCL2 is replaced with pyroglutamate (pE) by glutaminyl cyclase (QC) and isoQC. pE-CCL2 is stable and resistant to peptidases. …