
Role of CCL2/CCR2 axis in the immunopathogenesis of …
2021年3月15日 · Evidence suggests that uncontrolled immune system responses and their components play a significant role in developing rheumatoid arthritis (RA), which is considered …
CCL2 / CCR2轴在类风湿关节炎免疫发病机制中的作用:最新证据 …
ccl2或单核细胞趋化蛋白1(mcp-1)被称为cc趋化因子,可诱导单核细胞和巨噬细胞向损伤部位移动和募集。当ccl2结合其受体(其中最重要的是ccr2)时,会触发各种信号通路,最终导致各 …
Role of CCL2/CCR2 axis in the immunopathogenesis of …
2021年3月15日 · Therefore, CCL2/CCR2 axis could be one of the critical points in RA progression and considered a potential therapeutic target in the immunotherapy of RA patients. In this …
Chemokines in rheumatic diseases: pathogenic role and ... - Nature
2019年11月8日 · Synovial macrophages are the main producers of CXCL8 in patients with RA whereas neutrophils are an important source of CXCL2 in the K/BxN serum transfer mouse …
Chemokine Signaling Pathway Involved in CCL2 Expression in …
2015年7月1日 · CCL2, CCL4, c-Jun, c-Fos, and CCR5 may play an important role in the recruitment of PB leukocytes into the RA joints. These data provide evidence that the …
Role of chemokine receptor 2 in rheumatoid arthritis: A research …
2023年3月1日 · CCR2 has long been considered as a promising target for the treatment of rheumatoid arthritis (RA). CCR2 exhibits different effects in RA. Further understanding of the …
Role of Chemokines and Chemokine Receptors in Rheumatoid Arthritis
Effect of current RA therapies on chemokines as well as the current chemokine targeted therapies in RA. Closed arrows indicate antagonism. Additionally, RA patients that responded to IL-1 …
Monocytes in rheumatoid arthritis: Circulating precursors of ...
2018年12月1日 · The activated monocytes pool in response to chemotactic ligands CCL2 and CX3CL1 migrate from the circulation into RA synovium and produce proinflammatory …
Enhancement of CCL2 expression and monocyte migration by …
2017年3月24日 · Monocyte chemoattractant protein-1 (MCP-1/CCL2) is the key chemokine that regulates migration and infiltration of monocytes. Here, we examined the role of CCN1 in …
Enhancement of CCL2 expression and monocyte migration by …
Monocyte chemoattractant protein-1 (MCP-1/CCL2) is the key chemokine that regulates migration and infiltration of monocytes. Here, we examined the role of CCN1 in monocyte migration, and …