2021年3月15日 · Evidence suggests that uncontrolled immune system responses and their components play a significant role in developing rheumatoid arthritis (RA), which is considered …

ccl2或单核细胞趋化蛋白1（mcp-1）被称为cc趋化因子，可诱导单核细胞和巨噬细胞向损伤部位移动和募集。当ccl2结合其受体（其中最重要的是ccr2）时，会触发各种信号通路，最终导致各 …

2021年3月15日 · Therefore, CCL2/CCR2 axis could be one of the critical points in RA progression and considered a potential therapeutic target in the immunotherapy of RA patients. In this …

2019年11月8日 · Synovial macrophages are the main producers of CXCL8 in patients with RA whereas neutrophils are an important source of CXCL2 in the K/BxN serum transfer mouse …

2015年7月1日 · CCL2, CCL4, c-Jun, c-Fos, and CCR5 may play an important role in the recruitment of PB leukocytes into the RA joints. These data provide evidence that the …

2023年3月1日 · CCR2 has long been considered as a promising target for the treatment of rheumatoid arthritis (RA). CCR2 exhibits different effects in RA. Further understanding of the …

Effect of current RA therapies on chemokines as well as the current chemokine targeted therapies in RA. Closed arrows indicate antagonism. Additionally, RA patients that responded to IL-1 …

2018年12月1日 · The activated monocytes pool in response to chemotactic ligands CCL2 and CX3CL1 migrate from the circulation into RA synovium and produce proinflammatory …

2017年3月24日 · Monocyte chemoattractant protein-1 (MCP-1/CCL2) is the key chemokine that regulates migration and infiltration of monocytes. Here, we examined the role of CCN1 in …

Monocyte chemoattractant protein-1 (MCP-1/CCL2) is the key chemokine that regulates migration and infiltration of monocytes. Here, we examined the role of CCN1 in monocyte migration, and …