2021年3月15日 · Evidence suggests that uncontrolled immune system responses and their components play a significant role in developing rheumatoid arthritis (RA), which is considered an autoimmune disease (AD). Among immune system mediators, cytokines and chemokines are involved in numerous physiological and patholo …

ccl2或单核细胞趋化蛋白1（mcp-1）被称为cc趋化因子，可诱导单核细胞和巨噬细胞向损伤部位移动和募集。当ccl2结合其受体（其中最重要的是ccr2）时，会触发各种信号通路，最终导致各种免疫事件，例如炎症。

2021年3月15日 · Therefore, CCL2/CCR2 axis could be one of the critical points in RA progression and considered a potential therapeutic target in the immunotherapy of RA patients. In this review, CCL2/CCR2 axis biology, its role in the immune responses and RA pathogenesis, as well as the outcome of CCL2/CCR2 axis targeting are discussed.

2019年11月8日 · Synovial macrophages are the main producers of CXCL8 in patients with RA whereas neutrophils are an important source of CXCL2 in the K/BxN serum transfer mouse model of arthritis 25, 38, 39....

2015年7月1日 · CCL2, CCL4, c-Jun, c-Fos, and CCR5 may play an important role in the recruitment of PB leukocytes into the RA joints. These data provide evidence that the chemokine signaling pathway is involved in CCL2 expression in RA patient tissues, which may contribute to chronic inflammation associated with RA.

2023年3月1日 · CCR2 has long been considered as a promising target for the treatment of rheumatoid arthritis (RA). CCR2 exhibits different effects in RA. Further understanding of the role of CCR2 could promote the development of its targeted drugs and provide new ideas for improving CCL2-mediated inflammatory diseases.

Effect of current RA therapies on chemokines as well as the current chemokine targeted therapies in RA. Closed arrows indicate antagonism. Additionally, RA patients that responded to IL-1 receptor antagonist (IL-1Ra) therapy had significantly lower mean changes in the serum CCL2 and CCL3 levels compared to non-responders or placebo.

2018年12月1日 · The activated monocytes pool in response to chemotactic ligands CCL2 and CX3CL1 migrate from the circulation into RA synovium and produce proinflammatory cytokines. Hence, their role in RA due to active participation in the perpetuation of synovial inflammation cannot be neglected.

2017年3月24日 · Monocyte chemoattractant protein-1 (MCP-1/CCL2) is the key chemokine that regulates migration and infiltration of monocytes. Here, we examined the role of CCN1 in monocyte migration, and...

Monocyte chemoattractant protein-1 (MCP-1/CCL2) is the key chemokine that regulates migration and infiltration of monocytes. Here, we examined the role of CCN1 in monocyte migration, and CCL2 expression in osteoblasts. We found higher levels of CCN1 and CCL2 in synovial fluid from RA patients compared with levels from non-RA controls.