Chemokine (C-C motif) ligand 21 (CCL21) is a small cytokine belonging to the CC chemokine family. This chemokine is also known as 6Ckine (because it has six conserved cysteine residues instead of the four cysteines typical to chemokines), exodus-2, and secondary lymphoid-tissue chemokine (SLC).

2024年12月24日 · CCL21 (C-C Motif Chemokine Ligand 21) is a Protein Coding gene. Diseases associated with CCL21 include Periapical Periodontitis and Scrapie. Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include chemokine activity …

CCL21，又称 exodus-2、次级淋巴组织趋化因子 (SLC)，属于 CC 趋化因子家族的一种小细胞因子，在人类基因组中位于第 9 号染色体上。 CCL21可以在淋巴管起始处和淋巴器官中组成型表达，存在于几种基质细胞和高内皮小静脉 (HEV) 上，可以与糖胺聚糖 (GAG) 结合并固定 ...

CCL21 promotes immune activity in the tumor microenvironment (TME) by colocalizing dendritic cells (DC) and T cells programing ectopic lymph node architectural structures that correlate with cancer prognosis. Innovative strategies to deliver CCL21 in cancer patients will reactivate the downregulated …

2021年7月23日 · CCL21 is constitutively expressed by lymphatic endothelial cells and is essential for guiding DCs to the lymph nodes. Two mouse genes encode functional CCL21 variants, CCL21-Ser and...

In autoimmune diseases, CCL21 promotes the adhesion and migration of various immune cells, including T lymphocytes, macrophages, and neutrophils, by high-affinity binding to CCR7. It is also widely expressed in non-lymphocytes and participates in the regulation of angiogenesis and osteoclastogenesis [34,35].

CCL21/CCR7 prevents apoptosis by upregulating the expression of bcl-2 and by downregulating the expression of bax and caspase-3 potentially via the ERK pathway in non-small cell lung cancer cell lines; CCL21 was more localized to chondrocytes and meniscal cells during the development of osteoarthritis in mice.

CCL21 is a homeostatic lymphoid chemokine instrumental in the recruitment and organization of T cells and dendritic cells into lymphoid T areas. In human secondary lymphoid organs (SLOs), CCL21 is produced by cells distributed throughout the T zone, whereas high endothelial venules (HEVs) lack CCL21 mRNA.

趋化因子ccl21属于cc类趋化因子,主要表达于周围淋巴组织.研究表明,ccl21可以促使血管内皮 细胞黏附流动的t细胞参与淋巴细胞归巢,能够很强地趋化t,b淋巴细胞,成熟树突状细胞(dc)及nk细胞,参与t细胞免疫应答.ccl21可以募集活化 效应细胞,使其肿瘤周围聚集,在肿瘤 ...

It is a high affinity functional ligand for Chemokine Receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19). [provided by RefSeq, Sep 2014]