Chemokine (C-C motif) ligand 28 (CCL28), also known as mucosae-associated epithelial chemokine (MEC), CCK1 and SCYA28, is a chemokine. CCL28 regulates the chemotaxis of cells that express the chemokine receptors CCR3 and CCR10 .

2024年12月24日 · CCL28 (C-C Motif Chemokine Ligand 28) is a Protein Coding gene. Diseases associated with CCL28 include Pancreatitis and Acute Hemorrhagic Pancreatitis . Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway .

MEC/ CCL28 Protein, Human 是一种 CC 趋化因子，几乎存在于所有粘膜组织中，可作为粘膜表面的统一免疫刺激剂。 CCL28 可以与 CCR3 和 CCR10 结合作用，介导免疫反应，病毒感染，癌症以及抗菌作用。 MEC/ CCL28 Protein, Human 一种由 E. coli 表达的重组人 MEC/ CCL28 (S20-Y127) 蛋白。 MEC/ CCL28 Protein, Mouse 是一种 CC 趋化因子，几乎存在于所有粘膜组织中，可作为粘膜表面的统一免疫刺激剂。 CCL28 可以与 CCR3 和 CCR10 结合作用，介导免疫反 …

CCL28, β- or CC chemokine, is involved in the host immunity at various epithelial and mucosal linings. The unique roles of CCL28 in several facets of immune responses have attracted considerable attention and may represent a promising approach to combat various infections.

CCL28 displays strong homing capabilities for B and T cells at several mucosal and epithelial sites, and orchestrates the trafficking and functioning of lymphocytes. The chemotactic and immunomodulatory features of CCL28 through the interactions with its chemokine receptors, CCR10 and CCR3, will also be discussed in detail.

2016年11月15日 · In this study, we found that hypoxia hepatocellular carcinoma (HCC) cells recruited Regulatory T cells (Tregs) and expressed more Chemokine (C-C motif) ligand 28 (CCL28). Deletion of CCL28 inhibited Treg recruitment. Furthermore, overexpression of CCL28 promoted tumor growth and Treg infiltration in vivo.

2017年10月1日 · CCL28 is a β- or CC chemokine that is involved in host immunity through the interactions with its chemokine receptors, CCR10 and CCR3. CCL28 is constitutively expressed in a wide variety of tissues including exocrine glands …

ccl28是新近发现的趋化性细胞因子家族cc类中的成员.多种粘膜组织的上皮细胞可以产生ccl28.其受体为ccr10和ccr3.通过与相应受体结合,cc128可介导血循环中的cd4+t细胞、cd8+t细胞、iga抗体分泌细胞(asc)等免疫活性细胞归巢迁徙至相关组织;另外,ccl28还具有明显的广谱抗微 ...

2023年3月27日 · Experiments showed that under the hypoxia condition, HIF-1α was upregulated, which can directly bind to the promoter region of CCL28 and lead to its higher level. Also, CCL28 secreted by lung cancer cells could induce Tregs infiltration. Our study provides a novel insight focused on the chemokines in lung cancer immunotherapy.

2024年2月1日 · SPDEF can suppress immune evasion of CRC cells by activating CCL28, which is achieved through the modulation of M2 polarization of macrophages. This provides a new research direction and potential therapeutic target for immunotherapy in CRC.