2024年12月24日 · CCNE1 (Cyclin E1) is a Protein Coding gene. Diseases associated with CCNE1 include Pancreatic Cancer and Ovarian Cancer. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Defective binding of RB1 mutants to E2F1, (E2F2, E2F3).

G1/S-specific cyclin-E1 is a protein that in humans is encoded by the CCNE1 gene. [5] The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK.

2022年4月20日 · To uncover therapeutic targets for tumours with CCNE1 amplification, we undertook genome-scale CRISPR–Cas9-based synthetic lethality screens in cellular models of CCNE1 amplification. Here we...

由该基因编码的蛋白质属于高度保守的细胞周期蛋白家族，其成员的特点是在整个细胞周期中蛋白质丰度具有显着的周期性。 细胞周期蛋白作为 CDK 激酶的调节剂发挥作用。 不同的细胞周期蛋白表现出不同的表达和降解模式，这有助于每个有丝分裂事件的时间协调。 该细胞周期蛋白与 CDK2 的调节亚基形成复合物并发挥作用， CDK2 的活性是细胞周期 G1/S 转换所必需的。 这种蛋白质在 G1-S 期边界积累，并随着细胞通过 S 期而降解。 已在许多肿瘤中观察到该基因的过度表达， …

These studies demonstrate that CCNE1 CN is a clinically tractable biomarker predicting responsiveness to low-dose WEE1i-ATRi for aggressive subsets of OVCAs/EMCAs. Gynecological cancers can be heterogeneous in anatomic location, histology, and genomics.

2023年2月16日 · 细胞周期蛋白E1 (CCNE1)是细胞周期由G1期向S期转变的关键调节因子，它能够激活细胞周期蛋白依赖性激酶2（CDK2）， 使其进入S期并促进DNA复制。 CCNE1的过度表达通过加速S期进入，影响中心体扩增和刺激有丝分裂进程加速，从而解除对G1/S和G2/M期细胞周期的调控。 CCNE1基因的扩增常见于多种类型的肿瘤，尤其是在高级别浆液性卵巢癌、子宫肿瘤和胃食道肿瘤中。 CCNE1的高度表达与基因组不稳定、全基因组倍增以及细胞毒性和靶向治疗的 …

2025年2月9日 · CCNE1 Is a Putative Therapeutic Target for ARID1A-Mutated Ovarian Clear Cell Carcinoma. Cyclin E1 expression and malignancy in meningiomas. Reduced RBX1 expression induces chromosome instability and promotes cellular transformation in high-grade serous ovarian cancer precursor cells.

2023年3月24日 · Our study demonstrated that CCNE1 is upregulated in multiple cancers in the TCGA database and may be a promising predictive biomarker for the immunotherapy response in some types of cancers. Moreover, CCNE1 knockdown can suppress the proliferation, migration and invasion of UCEC cells.

2020年5月5日 · CCNE1 amplification has been identified as a primary oncogenic driver in a subset of high grade serous ovarian cancer that have an unmet clinical need. Understanding the interplay between cyclin E1 amplification and other common ovarian cancer genetic alterations provides the basis for chemotherapeutic resistance in CCNE1 amplified disease.

摘要： 细胞周期蛋白E1（Cyclin E1），是由CCNE1基因编码的一种核蛋白，在细胞周期中表现为循环式的表达，在整个细胞周期进程中发挥至关重要的作用。该蛋白通过激活细胞周期蛋白依赖性激酶2（CDK2）并与之形成复合物，促进细胞通过细胞周期G1/S期限制点 ...