CCR6 is an important receptor that is involved in regulating several aspects of mucosal immunity, including the ability to mediate the recruitment of immature dendritic cells (DCs) and mature DCs, and professional antigen presenting cells (APCs) to the sites of epithelial inflammation.

Chemokine receptor 6 also known as CCR6 is a CC chemokine receptor protein which in humans is encoded by the CCR6 gene. [5] CCR6 has also recently been designated CD196 (cluster of differentiation 196). The gene is located on the long arm of Chromosome 6 …

收集野生型C57BL/6和纯合B-hCCR6小鼠的脾细胞，并用种属特异性抗CCR6抗体进行流式细胞术分析。 结果显示：鼠CCR6仅在野生小鼠中检测到，人CCR6仅在纯合B-hCCR6小鼠中检测到。

2024年1月12日 · CCR6是一种G蛋白偶联趋化因子受体，与CCL20紧密结合形成一对具有高度亲和力和“专一性”的趋化因子受配体。 大量研究表明，CCR6与多种炎症性疾病相关，并且在多种消化系统肿瘤的发生与发展中发挥重要作用。

CXCR6是一种 G 蛋白偶联受体，具有七个跨膜结构域，属于 CXC 趋化因子受体家族。 重点： 1. CXCR6对于由 CD8+细胞毒性T细胞 (CTL)介导的持续肿瘤控制至关重要； 2. CXCR6优化CTL与传统DC的CCR7+ DC3状态的相互作用； 3.

2006年8月1日 · 摘要：CCR6 趋化因子受体由肠道粘膜免疫系统中发现的大多数 B 细胞和 T 细胞亚群以及树突状细胞 (DC) 表达。 CCL20 是 CCR6 的单一趋化因子配体，由覆盖在 Peyer 集结 (PP) 和分离的淋巴滤泡 (ILF) 上的滤泡相关上皮 (FAE) 选择性制备。

CCR6 is an important receptor that is involved in regulating several aspects of mucosal immunity, including the ability to mediate the recruitment of immature dendritic cells (DCs) and mature DCs, and professional antigen presenting cells (APCs) to the sites of epithelial inflammation.

2024年12月24日 · CCR6 (C-C Motif Chemokine Receptor 6) is a Protein Coding gene. Diseases associated with CCR6 include Diffuse Cutaneous Systemic Sclerosis and Limited Scleroderma. Among its related pathways are Class A/1 (Rhodopsin-like …

Detailed analysis of CCR6 and its CC chemokine ligand may shed new light on the control of DC migration and function, providing a potential therapeutic avenue for treatment of a wide range of pathologies including HIV infection, autoimmunity, and transplant rejection.

Expression of GPR-CY4 mRNA in CD4 (+) and CD8 (+) T cells was strongly up-regulated by IL-2. Based on these data GPR-CY4 was shown to be the specific receptor for LARC and was designated as CCR6. So far LARC, produced by activated macrophages, dendritic cells and endothelial cells, is the only high affinity ligand and potent agonist for CCR6.