2025年3月14日 · CCR8, like other chemokine receptors, is a GPCR with a seven-transmembrane (7TM) domain embedded in the cell membrane. This structure enables conformational changes upon ligand binding, facilitating intracellular signaling.

2024年2月2日 · Understanding the molecular recognition of CCR8, particularly with nonpeptide ligands, is valuable for drug development. Here, we report three cryo–electron microscopy structures of human CCR8 complexed with G i trimers in the ligand-free state or activated by nonpeptide agonists LMD-009 and ZK 756326.

2016年7月29日 · Our findings confirm a recent in silico study of CCR8, which predicts the involvement of the 7TM bridge in binding of both peptide and non-peptide ligands (39). Each bridge has been shown to be required for chemokine binding to other chemokine receptors, including CCR5 ( 40 ), CXCR2 ( 41 ), and CXCR1 ( 42 ).

Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell Apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues.

Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection. Was originally thought to be a receptor for SCYA3 and SCYA17. Gene Ontology (GO) annotations organized by slimming set. Cell membrane ; Multi-pass membrane protein.

We find that the seven-transmem-brane (TM) receptor conserved disulfide bridge (7TM bridge) linking transmembrane helix III (TMIII) and ECL-2 is crucial for chemokine and small molecule action, whereas the chemo-kine receptor conserved disulfide bridge between the N termi-nus and TMVII is needed only for chemokines.

2016年7月29日 · Here we investigate the importance of conserved extracellular disulfide bridges and aromatic residues in extracellular loop 2 (ECL-2) for ligand binding and activation in the chemokine receptor CCR8. We used inositol 1,4,5-trisphosphate accumulation and radioligand binding experiments to determine the impact of receptor mutagenesis on both ...

CCR8（Chemokine receptor 8） 是一种七跨膜G蛋白偶联受体，属于趋化因子受体C-C亚家族。 CCR8在Th2细胞、单核细胞和NK细胞上有表达，在Th1细胞上不表达。 此外，CCR8在Treg细胞中也有表达，在肿瘤浸润的Treg细胞中高表达，在胸腺、脾脏和外周血的Treg细胞中表达量较低。 CCR8通过与其配体的相互作用参与了多种肿瘤的发展进程以及介导了肿瘤的免疫。 肿瘤部位的Treg上的CCR8特异性高表达表明CCR8是肿瘤部位的Treg细胞的非常好的生物标志物，是极 …

CCR8 是 CC基序趋化因子受体 8（hemokine (C-C motif) receptor 8），作为一种在肿瘤浸润的调节性T细胞（Treg）上特异性高表达的趋化因子受体，其属于 G蛋白偶联受体 。CCR8有四种已知配体： CCL1 、CCL8、CCL16和CCL18。

2024年2月3日 · 徐菲团队在国际学术期刊《科学进展》(Science Advances)上发表题为“Unveiling the structural mechanisms of nonpeptide ligand recognition and activation in human chemokine receptor CCR8”的研究论文，揭示了趋化因子受体CCR8识别非肽配体并激活的分子机制。