Jan 30, 2025 · Recent studies demonstrate that CC chemokine receptor (CCR)8 is highly and specifically expressed on effector TI-Treg cells in mice and humans, highlighting CCR8 as a …

2 days ago · It has been previously reported that CCR8 + Tregs suppress the proliferation of CD8 + T cells. 46, 47 Preclinical models have shown that Treg-depleting anti-CCR8 agents …

Mar 30, 2022 · Recent studies identified selective CCR8 expression on tumor-infiltrating Tregs; CCR8+ Tregs have been indicated as a possible new target of cancer immunotherapy. Here, …

Recent studies demonstrate that CC chemokine receptor (CCR)8 is highly and specifically expressed on effector TI-Treg cells in mice and humans, highlighting CCR8 as a promising …

18 hours ago · Data from AbbVie’s immuno-oncology platform highlight the potential of a novel CCR8-targeting antibody, ABBV-514, in driving anti-tumor immunity. 2 CCR8 is a promising …

We generated two CCR8-specific nanobodies (Nbs) that recognize distinct epitopes on the CCR8 extracellular domain. These Nbs were formulated as tetravalent Nb-Fc fusion proteins for …

2 days ago · ABBV-514 is an investigational anti-chemokine C-C motif receptor 8 (CCR8) antibody that is being investigated for the treatment of relapsed non-small cell lung cancer …

Jul 23, 2024 · In this study, we show that an increase in glucocorticoid caused by brain tumors leads to an enhanced expression of CCR8 on T cells, which in turn results in the sequestration …

Jun 6, 2017 · We show that in human peripheral blood cells, more than 30% of T reg up-regulate CCR8 following activation in the presence of CCL1. This interaction induces STAT3 …

CCR8 is a cell surface receptor that belongs to class A of the G protein-coupled receptor (GPCR) family. It contains seven transmembrane domains, three extracellular loop domains and three …