Chemokine (C-C motif) receptor 8, also known as CCR8, is a protein which in humans is encoded by the CCR8 gene. [5] CCR8 has also recently been designated CDw198 (cluster of differentiation w198).

2024年12月24日 · CCR8 (C-C Motif Chemokine Receptor 8) is a Protein Coding gene. Diseases associated with CCR8 include Molluscum Contagiosum and Kaposi Sarcoma. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling.

CCR8 is expressed by a small and heterogeneous population of peripheral blood CD4 memory T cells enriched in T helper type 2 (Th2) effector and T regulatory (Treg) cells. CCR8 mediates rescue from dexamethasone-induced apoptosis via an ERK-dependent pathway

2025年2月1日 · Recent studies demonstrate that CC chemokine receptor (CCR)8 is highly and specifically expressed on effector TI-Treg cells in mice and humans, highlighting CCR8 as a promising target for selective TI-Treg cell depletion in the treatment of various cancers.

CCR8 expressed on Chinese hamster ovarian (CHO) cells mediated robust G protein activation, inhibition of cAMP synthesis and β-arrestin2 recruitment in response to CCL1 but not CCL18. Several N- and C-terminal variants of CCL18 also failed to stimulate CCR8 activation.

Characterized as a seven-transmembrane protein similar to G protein-coupled receptors, the CCR8 gene codes a member of the beta chemokine receptor family. Migration of different immune cell types to areas of inflammation depends on these receptors and their ligands.

2024年11月27日 · This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites.

This gene encodes a member of the beta Chemokine Receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites.

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites.

2016年9月14日 · Gene target information for CCR8 - C-C motif chemokine receptor 8 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.