We newly identified CCR8 expression on a subgroup of intestinal ILCs producing IFN-γ and linked a functional CCL1/CCR8 axis with their abundance in the gut suggesting that this pathway axis supports tissue-specific ILC functions important for intestinal homeostasis.

20 小时之前 · a–i The expression levels of intestinal immune response genes (Ccr2, CcR3, Ccr5, Cxcr6, Ccr8, Ccl3, Ccl4, IFN-γ, and IL-17a) in the MLN were determined through quantitative PCR; *p < 0.05 ...

2021年6月1日 · We characterized a selection of these CCR8 ligands (hCCL1, vCCL1, ZK756326, AZ6; CCR8 agonists and a naphthalene-sulfonamide-based CCR8 antagonist), in in vitro cell-based assays (hCCL1 AF647 binding, calcium mobilization, cellular impedance, cell migration, β-arrestin 1/2 recruitment), and used pharmacological tools to determine G protein ...

2021年2月9日 · Here, we analyzed the role of CCR8 in the context of intestinal inflammation. We found that CCR8 signaling protects mice from acute intestinal damage and that this function is selectively mediated by the ligand CCL1. We newly identified CCR8 expression on a subgroup of intestinal ILCs producing IFN-g and linked a functional CCL1/CCR8 axis

2025年1月30日 · Recent studies demonstrate that CC chemokine receptor (CCR)8 is highly and specifically expressed on effector TI-Treg cells in mice and humans, highlighting CCR8 as a promising target for selective TI-Treg cell depletion in the treatment of various cancers.

为了进一步表征肠道炎症中这种复杂的免疫细胞网络，我们使用实验性炎症小鼠模型研究了趋化因子受体CCR8对结肠炎的发展贡献。 我们发现CCR8 -/- 与野生型对照相比，小鼠表现出强烈的体重减轻，并伴有粘膜损伤的组织学和内窥镜症状增加。 进一步的实验表明，CCR8的这种肠道保护功能似乎是由趋化性配体CCL1选择性介导的，而趋化性配体CCL1特别是在结肠炎期间由肠道巨噬细胞产生。 此外，我们新发现了在肠固有淋巴样细胞亚群中产生IFN-γ的CCR8表达，并将功能 …

2006年11月15日 · Using a fluorescent form of the ligand selective for CCR8 (F-CCL1), we identified the leukocytes expressing CCR8 in human, monkey, and mouse peripheral blood. CCR8 expression is primarily restricted to a subset of human CD4 memory T lymphocytes (15%).

2021年2月1日 · Moreover, we newly identified CCR8 expression on a subgroup of intestinal innate lymphoid cells producing IFN-γ and linked a functional CCL1/CCR8 axis with their abundance in the gut. Our...

1998年7月15日 · In this study we report the cloning of the murine CCR8 receptor (mCCR8). mCCR8 is also expressed mainly in the thymus. In the periphery, mCCR8 mRNA was found in significant amounts only in activated Th2 T cells. These cells respond in chemotaxis assays to known CCR8 ligands.

2011年1月9日 · Mouse CCL8 is a CC chemokine of the monocyte chemoattractant protein (MCP) family whose biological activity and receptor usage have remained elusive. Here we show that CCL8 is highly expressed...