CCR8（Chemokine receptor 8） 是一种七跨膜G蛋白偶联受体，属于趋化因子受体C-C亚家族。 CCR8在Th2细胞、单核细胞和NK细胞上有表达，在Th1细胞上不表达。 此外，CCR8在Treg细胞中也有表达，在肿瘤浸润的Treg细胞中高表达，在胸腺、脾脏和外周血的Treg细胞中表达量较低。 CCR8通过与其配体的相互作用参与了多种肿瘤的发展进程以及介导了肿瘤的免疫。 肿瘤部位的Treg上的CCR8特异性高表达表明CCR8是肿瘤部位的Treg细胞的非常好的生物标志物，是极 …

2025年1月30日 · Anti-CCR8 mAb therapy was shown to promote the expansion of tumor-specific CD8 + T cells and induce durable memory responses in the CT26 tumor-bearing colorectal carcinoma mouse model, significantly improving the therapeutic efficacy of PD-1 blockade .

2023年12月1日 · Here, authors generated mAb1, an antagonist antibody against CCR8 and determined structures of CCR8 in complex with mAb1 or the agonist CCL1, providing insights into CCR8 inhibition and...

As a consequence, anti-CCR8 depleting antibodies represent a novel highly promising immuno-therapy approach due to their potential to modulate the tumor micro-environment (TME) and to enhance anti-tumor immune responses. Methods At Domain Therapeutics, we have discovered a novel anti-CCR8 mAb candidate named DT-7012 that was fully characterized.

Recently, CCR8+Treg cells have been suggested to be a master regulator in the immunosuppressive tumor microenvironment; therefore, developing sensitive monoclonal antibodies (mAbs) for CCR8 has been desired. This study established a specific and sensitive mAb for mouse CCR8 (mCCR8), which is useful for flow

(mAbs) for CCR8. This study developed a specific mAb for human CCR8 (hCCR8), which is useful for flow cytometry by employing the Cell-Based Immunization and Screening (CBIS) method. The established anti-hCCR8 mAb, C8Mab-21, (mouse IgM, kappa) reacted with hCCR8-overexpressed Chinese hamster ovary-K1

In this study, we have developed an anti-mouse CCR8 (mCCR8) mAb (clone C 8 Mab-1, rat IgG 2a, kappa) using the Cell-Based Immunization and Screening (CBIS) method. We showed that C 8 Mab-1 and its recombinant antibody (recC 8 Mab-1) bind to mCCR8-overexpressed Chinese hamster ovary (CHO)-K1 cells (CHO/mCCR8), but not to the parental CHO-K1 ...

Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection. 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol. Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

In this study, we have developed an anti-mouse CCR8 (mCCR8) mAb (clone C 8 Mab-3, rat IgG 1, kappa) using the Cell-Based Immunization and Screening (CBIS) method. We revealed that C 8 Mab-3 and its recombinant antibody (recC 8 Mab-3) bind to mCCR8-overexpressed Chinese hamster ovary (CHO)-K1 cells (CHO/mCCR8), but not to the parental CHO-K1 ...

C-C motif chemokine receptor 8 (CCR8) is a G protein-coupled receptor predominantly expressed in regulatory T (Treg) and T helper 2 cells. The evidence that CCR8 expression in Treg is increased in cancers, CCR8 increases migration activity of Treg, and CCR8 induces the anti-apoptotic activity in T c …