2025年1月30日 · Analysis of The Cancer Genome Atlas (TCGA) data from patients with muscle-invasive bladder cancer (MIBC) showed that the highest gene enriched pathway in tumors bearing high CCR8 expression, involved the JAK-STAT signaling pathway, compared with tumors with low CCR8 expression .

2022年3月30日 · These findings reveal the significance of CCR8+ Tregs for immunosuppression in lung cancer, especially via cytotoxic T lymphocyte cell suppression, and suggest the potential value of...

In TCGA, CCR8 gene expression was found to be higher in primary tumors than in normal adjacent tissues across many indications . We assessed surface expression of CCR8 by flow cytometry and found preferential expression of CCR8 on tumor Tregs as compared to both peripheral Tregs and tumor and peripheral non-Treg CD4+ cells (referred to as T ...

2024年7月30日 · Chemokine (C-C motif) receptor 8 (CCR8) is a chemokine receptor selectively expressed on tumor-infiltrating regulatory T cells (Tregs). Strong immunosuppression mediated by CCR8 + Tregs observed in breast and lung malignancies suggest for their functional significance in cancer therapy.

2024年4月28日 · 通过在癌症基因组图谱（The Cancer Genome Atlas，TCGA）数据库中对胃癌差异表达基因和生存的分析发现了包括CCR8在内的8个关键基因，证明在胃癌中CCR8是影响肿瘤发生、发展的重要因素 [16] 。

This analysis will encompass the correlations between CCR8 subunit expression levels and tumor immune infiltration levels (B cells, CD4 T cells, CD8 T cells, neutrophils, macrophages, and dendritic cells) and investigate the impact of CCR8 expression on …

CCR8-targeting antibodies effectively delayed CT26 subcutaneous tumor growth, by proficiently reducing the proportion of tumor-infiltrating Tregs in CD4 + T cells. Specifically, we demonstrated a marked reverse of the exhausted state of CD4 + T convs and CD8 + T cells by targeting CCR8, both in vivo and ex vivo.

We generated two CCR8-specific nanobodies (Nbs) that recognize distinct epitopes on the CCR8 extracellular domain. These Nbs were formulated as tetravalent Nb-Fc fusion proteins for optimal CCR8 binding and blocking, containing either an antibody-dependent cell-mediated cytotoxicity (ADCC)-deficient or an ADCC-prone Fc region.

Recent studies demonstrate that CC chemokine receptor (CCR)8 is highly and specifically expressed on effector TI-Treg cells in mice and humans, highlighting CCR8 as a promising target for selective TI-Treg cell depletion in the treatment of various cancers.

2020年5月4日 · CCR8 blockade promotes Treg destabilization, reactivates the antitumor activity and improves the efficacy of PD-1 inhibitor a MIBC tissues were digested, incubated with control or CCR8-neutralizing antibody, and subjected to flow cytometry analysis to determine the molecules expression in Tregs.