SRF114是一种人IgG1抗CCR8的单抗，靶向肿瘤Treg细胞，并通过活化NK细胞诱导抗体依赖性细胞介导的细胞毒作用（ADCC），从而达到选择性消耗免疫抑制性肿瘤T调节细胞（Tregs），并同时保留外周Tregs的目的。

2022年3月30日 · Recent studies identified selective CCR8 expression on tumor-infiltrating Tregs; CCR8+ Tregs have been indicated as a possible new target of cancer immunotherapy. Here, we investigated the...

2022年2月15日 · Despite induction of such potent tumor immunity, anti-CCR8 mAb treatment elicited minimal autoimmunity in mice, contrasting with systemic Treg depletion, which eradicated tumors but induced severe autoimmune disease.

High levels of expression of chemokine (C-C motif) receptor 8 (CCR8) discriminate Treg cells within tumours from those found in systemic lymphoid tissues. It has recently been proposed that disruption of CCR8 function using blocking anti-CCR8 antibodies results in reduced accumulation of Treg cells within tumours and disruption of their ...

2025年3月16日 · 近期研究表明，CCR8在效应TI-Treg细胞上高度表达，提示CCR8可能成为一个具有潜力的靶点，用于选择性靶向TI-Treg细胞的肿瘤治疗策略。

2025年2月1日 · Recent studies demonstrate that CC chemokine receptor (CCR)8 is highly and specifically expressed on effector TI-Treg cells in mice and humans, highlighting CCR8 as a promising target for selective TI-Treg cell depletion in the treatment of various cancers.

2017年5月22日 · The current study identifies CCR8 + regulatory T cells (T reg cells) as drivers of immunosuppression and provides compelling evidence of a self-feeding mechanism by which, at an autoimmune site, CCL1 produced by FOXp3 + T reg cells upregulates the expression of its own receptor, CCR8, on these cells, and potentiates their in vivo proliferation ...

2024年2月3日 · 2月2日，上海科技大学iHuman研究所徐菲团队在国际学术期刊《科学进展》 (Science Advances) 上发表题为“Unveiling the structural mechanisms of nonpeptide ligand recognition and activation in human chemokine receptor...

2024年4月28日 · CC族趋化因子受体8（CC chemokine receptor 8，CCR8）属于CC族趋化因子受体家族，其主要在肿瘤微环境中的Treg细胞上特异性高表达，而在周围正常组织和外周血中低表达，因此CCR8可以作为Treg细胞的一种特异性标志物，是一种有潜力的治疗靶点和生物标志物。 本文对近年来CCR8在不同瘤种中的研究进展进行了归纳和总结，以期为后续研究提供参考。 [关键词] 肿瘤；CC族趋化因子受体8；免疫治疗；靶向治疗.

2017年6月6日 · We show that in human peripheral blood cells, more than 30% of T reg up-regulate CCR8 following activation in the presence of CCL1. This interaction induces STAT3-dependent up-regulation of FOXp3, CD39, IL-10, and granzyme B, resulting in enhanced suppressive activity of these cells.