CD5 is a good immunohistochemical marker for T-cells, although not as sensitive as CD3. About 76% of T-cell neoplasms are reported to express CD5, and it is also found in chronic lymphocytic leukemia and mantle cell lymphoma (both being B cell malignancies), that do not express CD3.

Jan 30, 2025 · CD5 is a transmembrane glycoprotein found on the surface of thymocytes, T lymphocytes and some B lymphocytes (B1a).

Dec 24, 2024 · CD5 (CD5 Molecule) is a Protein Coding gene. Diseases associated with CD5 include Thymic Carcinoma and Prolymphocytic Leukemia. Among its related pathways are Hematopoietic Stem Cells and Lineage-specific Markers …

CD5 is a molecule involved in signal transduction through tyrosine phosphorylation of intracellular proteins. It plays a role in modulating signaling via antigen-specific receptor complexes in T and B lymphocytes, with high expression on mature T-lymphocytes and low expression on a subset of mature B-lymphocytes.

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CD5 is a negative regulator of B-cell receptor (BCR) signaling that is up-regulated after BCR stimulation and likely contributes to B-cell tolerance in vivo. However, CD5 is constitutively expressed on the B-1 subset of B cells.

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Jun 12, 2024 · CD5 is a critical regulatory molecule in the immune system, involved in modulating T cell and B cell functions, maintaining immune tolerance, and preventing autoimmune responses. Its clinical significance spans autoimmune diseases, cancer, and transplantation medicine.

The CD5 antigen is a 67 kDa transmembrane glycoprotein expressed on the surface of practically all mature human T-cells (about 10% of CD4+ T-cells being CD5 negative). In immature (CD34+) T-cells, CD5 is weakly expressed, the intensity of expression increasing with maturation.

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