Proto-oncogene c-KIT is the gene encoding the receptor tyrosine kinase protein known as tyrosine-protein kinase KIT, CD117 (cluster of differentiation 117) or mast/stem cell growth factor receptor (SCFR). [5] Multiple transcript variants encoding …

2022年6月9日 · CD117 is a proto-oncogene activated in GIST tumors, receptor for kit protein, a 145 kD tyrosine kinase growth factor receptor protein

CD117 is a type of receptor tyrosine kinase and a type of tumor marker. Also called c-kit and stem cell factor receptor. A protein found on the surface of many different types of cells. It binds to a substance called stem cell factor (SCF), which causes certain types of blood cells to grow.

CD117 is a transmembrane protein receptor encoded by the c-kit proto-oncogene. The CD117 ligand is stem cell factor, an important hematopoietic regulator. CD117 is present on approximately 4% of normal bone marrow mononuclear cells and in acute myelogenous leukemia (AML) and chronic myelogenous leuk …

2024年12月25日 · Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.

CD117 (KIT) is a type III receptor tyrosine kinase operating in cell signal transduction in several cell types. Normally KIT is activated (phosphorylated) by binding of its ligand, the stem cell factor. This leads to a phosphorylation cascade ultimately activating various transcription factors in di …

2024年6月20日 · CD117是原癌基因4q11-q12编码的111型跨膜蛋白酪氨酸激酶生长因子受体蛋白，分子量为145-160kDa，是干细胞因子（肥大细胞生长因子）的受体。 理论知识 【使用频率】★★★★

CD117 ，又名 c-Kit ，是一个 细胞因子受体 ，在造血干细胞和其它细胞类型的细胞表面表达。 CD117是 III型受体酪氨酸激酶 ，可结合干细胞因子。 当该受体结合到干细胞因子上，它就会形成一个二聚体，激活其内在的酪氨酸激酶活性，这会反过来磷酸化、激活传递 ...

2024年5月22日 · CD117，也称c-Kit，KIT或干细胞因子（SCF）受体，CD117是一种III型酪氨酸蛋白激酶，在细胞存活和增殖、造血、干细胞维持、配子发生、肥大细胞发育、迁移和功能的调节，黑色素生成中发挥重要作用。 CD117分布. CD117主要分布在粒细胞，黑色素细胞中，除此之外在神经元细胞，腺上皮细胞中也有表达，参与细胞的生长发育。 （数据来源 uniprot） CD117结构： CD117由存在于4号染色体长臂区域（4q11-4q13）的原癌基因编码，与RTK家族III类的其他 …

CD117, also known as c-kit, is a tyrosine kinase receptor that is expressed in most hemopoietic stem and progenitor cells, as well as mast cells. It is a marker used for the detection of mast cell disorders and identification of myeloblasts in acute leukemias.