Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is a protein that in humans is encoded by the ITGAL gene. [5] CD11a functions in the immune system. It is involved in cellular adhesion and costimulatory signaling. It is the target of the drug efalizumab.

CD11有4种亚家族成员（CD11a、CD11b、CD11c 和 CD11d）：CD11a是一种泛白细胞标志物，由B和T淋巴细胞、单核细胞、巨噬细胞、中性粒细胞、嗜碱性粒细胞和嗜酸性粒细胞表达；CD11b由大多数粒细胞、单核细胞/巨噬细胞、 NK 细胞 以及B细胞和T细胞亚群表达；CD11c在 …

设立分化簇 (CD) 命名系统的目的是对白细胞表面抗原进行分类。 最初，表面抗原是根据与它们结合的对应单克隆抗体进行命名。 随着各实验室逐渐发现抗原常能刺激产生多种单克隆抗体，因此需要采用一种统一的命名系统。 1982 年于巴黎举行的第 1 届国际人类白细胞分化抗原专题讨论会 (HLDA) 上通过了目前使用的命名系统。 根据该命名系统，已经充分表征的抗原将会分配数字（例如，CD1、CD2 等），而对于仅有一种单克隆抗体可以识别的抗原分子，则分配临时名 …

2024年2月27日 · CD11有4种亚家族成员（CD11a、CD11b、CD11c 和 CD11d）：CD11a是一种泛白细胞标志物，由B和T淋巴细胞、单核细胞、巨噬细胞、中性粒细胞、嗜碱性粒细胞和嗜酸性粒细胞表达；CD11b由大多数粒细胞、单核细胞/巨噬细胞、NK 细胞以及B细胞和T细胞亚群表达；CD11c在单核 ...

2019年4月9日 · Precise spatiotemporal regulation of leukocyte extravasation is key for generating an efficient immune response to injury or infection. The integrins LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18)...

Our results indicated that CD11a was essential for optimal CD8 T cell expansion in response to L. monocytogenes infection, implying that ICAM-1 may not always play a dominant role in CD11a-mediated T cell activation or that initiation/amplification of different immune responses may involve distinct integrin-ligand combinations.

CD11a is a panleukocyte marker that is expressed by various types of immune cells, including B- and T-lymphocytes, monocytes, macrophages, neutrophils, basophils, and eosinophils. AI generated definition based on: Atlas of Hematopathology, 2013

β2 (CD18) integrins with α-chains CD11a, -b, -c, and -d are important adhesion molecules necessary for leukocyte migration and cellular interactions. CD18 deficiency leads to recurrent bacterial infections and poor wound healing due to reduced migration of leukocytes to inflammatory sites.

Precise spatiotemporal regulation of leukocyte extravasation is key for generating an efficient immune response to injury or infection. The integrins LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) play overlapping roles in neutrophil migration because they bind the same as well as different ligands in response to extracellular signaling.

利用基因组学，作者观察到肺泡巨噬细胞中CD11a，即LFA-1(Itgal)和CD11c(Itgax)的高表达。 已知CD11a是免疫细胞在爬行和迁移过程中利用的重要粘附分子，CD11c没有已知的迁移功能。