2021年12月15日 · CD137 (4-1BB; TNFSR9) is an activation-induced surface receptor that through costimulation effects provide antigen-primed T cells with augmented survival, proliferation and effector functions as...

CD137 (4-1BB) is a member of the TNFR-family with co-stimulatory function, triggering pro-survival signals in activated T-cells. Upregulation of CD137 upon stimulation allows identifying and isolating live, human antigen-specific CD8+ T-cells of all ...

CD137 is a kind of costimulatory molecule that mediates T cell activation, which regulates the activity of immune cells in a variety of physiological and pathological processes. Targeting CD137 or its ligand (CD137L) has been studied, aiming to enhance anticancer immune responses.

2025年1月8日 · Recent work demonstrates that CD137, a well-known costimulatory molecule for T cells, is highly expressed on Tregs in pathological conditions, while its expression is minimal or negligible on peripheral Tregs.

CD137/CD137 ligand (CD137L) signalling primarily induces a potent cell-mediated immune response, while signalling of cell surface-expressed CD137L into antigen presenting cells enhances their activation, differentiation and migratory capacity.

2019年11月8日 · The expression of CD137 in immune cells and its role in promoting immune function against cancer have been well-characterized. In fact, CD137 agonists have been tested as anticancer agents with some success . However, the biological significance of CD137 expression in cancer still remains unclear.

Schwarz and colleagues emphasize the critical role of CD137-expressing regulatory T cells (Tregs) in modulating cancer progression, autoimmune control, and immune homeostasis.

2023年6月30日 · Pichler et al. found that the activating receptor, CD137 (4-1BB), was specifically expressed by Tex cells. CD137 signaling promoted TCR-independent proliferation and terminal differentiation of Tex cells. In murine tumor models, treatment with CD137 agonists specifically after anti-PD1 therapy improves anti-tumor responses.

2021年5月21日 · We found CD137 being expressed on monocytes of healthy controls and at even higher levels in patients with multiple myeloma or CLL. CD137 HI(GH) monocytes displayed a distinct phenotypic, transcriptomic, and metabolic profile. They possessed an increased phagocytic capacity enabling superior antibody-dependent phagocytosis (ADPC) of multiple ...

2021年1月26日 · The CD137 receptor (4-1BB, TNF RSF9) is an activation induced molecule expressed by antigen-specific T-cells. The engagement with its ligand, CD137L, is capable of increasing T-cell survival, proliferation, and cytokine production.