
CD14—细菌脂多糖的膜受体 - 知乎 - 知乎专栏
CD14 (cluster of differentiation 14)原称MY23抗原,是一种表面抗原,属细胞表面糖蛋白家族成员之一。 CD14基因编码的蛋白,优先表达于单核/巨噬细胞。 CD14是革兰阴性菌内毒素脂多糖 …
Cell Reports丨CD14在细胞内LPS传感中的独立于TLR4的关键作用
CD14 是一种糖磷脂酰肌醇锚定的质膜蛋白,在 LPS 介导的 TLR4 激活中具有长期确定的作用;CD14 与 LPS 结合并将 LPS 转移到 TLR4-MD2 复合物,从而启动 myddosome 组装和信号 …
神奇的脂多糖 - 知乎 - 知乎专栏
md2是一种特殊的外分泌蛋白,能帮助tlr4识别lps。 3种蛋白质(CD14、TLR4和MD2)的不同组合决定了TLR4对不同结构LPS的识别能力,其中跨膜蛋白TLR4起关键作用。
Computationally Designed Bispecific MD2/CD14 Binding Peptides …
2018年12月1日 · We used computational design methods to predict and optimize a total of 53 cyclic and linear peptides targeting myeloid differentiation 2 (MD2) and cluster of differentiation …
TLR4/CD14/MD2 Revealed as the Limited Toll-like Receptor
2022年12月15日 · We identified CD14 associated with unique characteristics of different serovars as the crucial factor of the TLR4/CD14/MD2 complex for Ct-mediated activation of the NF-κB …
Multifaceted role of CD14 in innate immunity and tissue …
2023年12月1日 · CD14 is a co-receptor of Toll-like receptor (TLR)− 4, with a critical role in innate immune responses. CD14 recognizes bacterial lipopolysaccharides, pathogen-, and damage …
Recent progress in the discovery of myeloid differentiation 2 (MD2 …
2018年6月1日 · Lipopolysaccharide (LPS) from the membrane of Gram-negative bacteria is recognized and extracted by LBP. CD14 then delivers LPS to the TLR4–MD2 complex. …
An examination of the LPS-TLR4 immune response through the …
2025年3月18日 · The three-dimensional structural pattern diagram of LBP, CD14, TLR4, MD-2, and TLR4-MD-2 complex and the binding pattern diagram of LPS and TLR4-MD2 complex. A …
Co-expression of MD2 and CD14 genes (human or mouse)
pDUO2-MD2/CD14 is an expression vector designed to co-express MD2 and CD14 genes known to interact with each other : human MD2 (480 bp) and human CD14 (1125 bp) or mouse MD2 …
LPS传递级联的重建揭示了LBP,CD14和TLR4-MD2中有效 ... - X …
脂多糖(LPS)是革兰氏阴性细菌外膜的主要成分,结合Toll样受体4(TLR4)-MD2复合物并激活先天免疫应答。 LPS结合蛋白(LBP)和CD14均催化LPS向TLR4-MD2的转移。
- 某些结果已被删除