Thrombomodulin (TM), CD 141 or BDCA-3 is an integral membrane protein expressed on the surface of endothelial cells and serves as a cofactor for thrombin. It reduces blood coagulation …

2016年12月2日 · The first functional analyses point to a high pro-inflammatory state of CD141+ compared to CD141- monocytes. Therefore we hypothesize that these monocytes may …

2016年8月8日 · Intratumoral dendritic cells (DC) bearing CD103 in mice or CD141 in humans drive intratumoral CD8 + T cell activation. Using multiple strategies, we identified a critical role …

2019年3月6日 · By in vitro gene expression profiling of differentiated human DCs, we identified CD141 and CD163 as surface markers for DC-10. The coexpression of CD141 and CD163 in …

Human CD141 + dendritic cells (DCs), specialized for cross-presentation, have been extensively studied in the development of DC-based therapy against cancer. A series of attempts was …

2017年10月29日 · Here, we exploit the fact that human CD141 + DC and CD1c + DC develop in humanized mice, to further explore their equivalency in vivo. Global transcriptome analysis of …

Here, we identified a CD141 hi DC present in human interstitial dermis, liver, and lung that was distinct from the majority of CD1c + and CD14 + tissue DCs and superior at cross-presenting …

Results: Almost one third of liver CD11c (+) myeloid DCs (mDCs) expressed CD141 compared to <5% of circulating mDCs. Hepatic CD141 (+) DCs demonstrated pro-inflammatory function in …

2025年2月27日 · Chu et al. 11 identified a unique population of immunoregulatory tissue-resident DCs known as CD141 + dermal dendritic cells (CD141 + DDCs), in human skin. These cells …

2010年6月7日 · We report the first detailed functional analysis of the human CD141+ DC subset. CD141+ DCs are found in human lymph nodes, bone marrow, tonsil, and blood, and the latter …