CD154, also called CD40 ligand or CD40L, is a protein that is primarily expressed on activated T cells [5] and is a member of the TNF superfamily of molecules. It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type.

CD154, also known as CD40 ligand, is a costimulatory molecule involved in humoral and adaptive immune responses upon pairing with its classical receptor, CD40. The CD154/CD40 dyad is a key participant in the pathogenesis of many autoimmune diseases, ...

CD154 is a marker of activation expressed on T cells induced through their T-cell receptor. We analysed CD4 T-cell responses in 72 patients with chronic or resolved HCV infection (23 treatment naïve, 49 treatment experienced, including 16 who had achieved a …

The interaction between CD40 and CD154 (CD40 ligand) is central in immunology, participating in CD4 + T cell priming by dendritic cells (DC), CD4 + T cell help to B cells and classical macrophage activation by CD4 + T cells. However, its role in the Th2 side of immunology including helminth infection remains incompletely understood.

The activation of the CD154-CD40 axis results in several events, including cytokine production, immunoglobulin gene switching, prevention of B-cell apoptosis, increased expression of costimulatory molecules such as CD80 and CD86, germinal center formation, production of high-affinity antibodies and formation of B memory cells.

CD154, also known as CD40 ligand, is a type 2 membrane protein expressed mainly by activated CD4+ T cells and to a lesser extent by other immune cells like CD8+ T cells, NK cells, and eosinophils. It plays a crucial role in the CD40-CD154 pathway interaction, which is essential for the induction of immune responses.

CD154, also known as CD40 ligand (CD40L), previously referred to as gp39, TRAP, or TBAM [2–4], is a 39 kDa type II membrane glycoprotein of the TNF family . Located on the long arm of the X chromosome, region q26.3–q27.1, the human CD154 gene …

2023年10月10日 · CD40L蛋白（CD40 ligand），也叫CD154，是细胞膜表面分子，主要由激活的CD4+ T淋巴细胞表达。 它与CD40受体结合，参与免疫应答的调节和维持。 在特定的细胞类型上，如B细胞、巨噬细胞、树突状细胞等，CD40L通过结合CD40分子来引发信号传导，并促进这些细 …

CD40 ligand, a type II transmembrane protein recently renamed CD154, was originally considered restricted to activated T lymphocytes, functioning as a mediator of T cell-dependent B cell activation, proliferation, and differentiation. However, the spectrum of CD154 expression and function has broade …

CD154 (CD40L) is a homotrimeric transmembrane TNFα-family protein that is expressed on the surface of activated CD4 + T cells and a wide range of other cell types [1–4]. CD154 can be proteolytically shed from membranes; the resulting soluble trimeric version can also be active on cells [1, 2, 4, 5]. The most important receptor for CD154 is ...