
CAR T-cell therapy is effective for CD19-dim B-lymphoblastic …
2019年11月18日 · Of those, 3 were CD19 dim or negative before CAR T-cell therapy, and 3 received prior blinatumomab with overlap of both in 1 patient (HP-34). Three CD19 …
Nature子刊:从患者筛选、桥接到清淋,详述如何准备CAR-T治疗
2022年3月25日 · CD19-dim(定义为白血病细胞上的CD19表达低于非恶性B细胞)更常见于既往接受过blinatumomab治疗的患者,且CD19-dim患者在接受抗CD19 CAR-T治疗后的结局不 …
Flow Cytometric Immunophenotypic Analysis in the Diagnosis …
The leukemic PCs often have lymphoplasmacytoid morphology and may even variably express CD19 with dim surface light chain expression in a subset of cases, mimicking B-cell lymphoma …
Diminished expression of CD19 in B-cell lymphomas - Wiley …
2004年12月10日 · Therefore, the expected sensitivity for identifying a CD19-dim malignant B-cell lymphoma cell using CD19 expression alone to identify the neoplastic cells is slightly higher …
CAR T-cell therapy is effective for CD19-dim B-lymphoblastic ... - PubMed
2019年11月26日 · The presence of dim CD19 or rare CD19- events by flow cytometry did not predict nonresponse or recurrence after CAR T-cell therapy. However, prior therapy with the …
Clinical Flow-Cytometric Testing in Chronic Lymphocytic Leukemia
CLL has a characteristic immunophenotype, expressing CD5, CD19, dim CD20, dim CD22, CD23, bright CD43, dim CD45, dim to negative CD79b, dim CD81, CD200, and dim monoclonal …
NK cells expressing the B cell antigen CD19 ... - Wiley Online Library
The CD19+CD56+ co-expressing cells (CD19+NK cells) are in green and both the FSC and SSC characteristics and CD19/CD56 dim pattern are shown. B- B cell associated antigens in …
CD19 negative and dim precursor B-lineage acute lymphoblastic …
However, this approach is not optimal in the diagnosis and follow-up of CD19 negative or dim B-ALLs. Though CD19 negative B-ALLs are rare, in the current era of CD19 targeted immuno …
Genetic mechanisms of target antigen loss in CAR19 therapy of …
2018年10月1日 · The CD19 status of these 32 patients at the time of relapse was: 14 CD19 –, 3 CD19 +, 1 CD19 dim, 5 CD19 +/−, and 9 unknown. The CD19 status of the 32 relapsed …
CD19 - Wikipedia
CD19 is widely expressed during all phases of B cell development until terminal differentiation into plasma cells. During B cell lymphopoiesis, CD19 surface expression starts during …