苏冰研究团队在Cellular & Molecular Immunology发表mTOR信号 …
2023年9月26日 · 该综述详细讨论了急性、慢性感染和肿瘤发生条件下CD8+ T细胞分化的异质性以及mTOR (重点阐述mTORC2/SIN1)信号通路在记忆T细胞和耗竭T细胞分化过程中的分子调控 …
Regulation of CD8 + T memory and exhaustion by the mTOR …
2023年8月15日 · In this review, we focus on mammalian target of rapamycin (mTOR), particularly signaling mediated by mTOR complex (mTORC) 2 in memory and exhausted CD8+ T cells at …
Phosphoproteomics of CD2 signaling reveals AMPK-dependent …
First, phosphoproteomics and Western blotting analyses revealed that CD2 modulated the phosphorylation of 40 kinases (table S4), including three kinases belonging to the mTOR …
CD226 maintains regulatory T cell phenotype stability and ... - Cell …
2023年10月31日 · CD226-deficient Treg cells exhibit reduced oxidative phosphorylation and increased glycolysis rates, which are regulated by the adenosine 5′-monophosphate-activated …
Roles of mTORC1 and mTORC2 in controlling γδ T1 and γδ T17 …
2020年1月30日 · In this study, we found that mTORC1 directs both the γδ T1 and γδ T17 differentiation of peripheral γδ T cells by the mechanisms involving glycolysis. mTORC2 …
mTORC1 and mTORC2 selectively regulate CD8⁺ T cell ... - PubMed
Activation of mTOR-dependent pathways regulates the specification and differentiation of CD4+ T effector cell subsets. Herein, we show that mTOR complex 1 (mTORC1) and mTORC2 have …
Cell子刊综述：一文详细了解mTOR对细胞代谢的调节 - 知乎
2023年9月4日 · 雷帕霉素靶点 （The target of rapamycin，TOR）对于大部分学者而言都不陌生，它是一种高度保守的丝氨酸/苏氨酸蛋白激酶，在调节细胞生长、新陈代谢过程中具有核心 …
Roles of mTORC1 and mTORC2 in controlling γδ T1 and γδ T17 ...
The metabolism-controlled differentiation of αβ T cells has been well documented; however, the role of a metabolism program in γδ T cell differentiation and function has not been clarified. …
mTOR信号通路 - 知乎 - 知乎专栏
mTOR是 PI3K 相关激酶(PIKK)家族中的丝氨酸/苏氨酸蛋白激酶，形成两个不同的蛋白复合物的催化亚基，称为mTOR复合物1 (mTORC1)和2 (mTORC2)（图1A）。mTORC1由其三个核心成 …
mTOR信号通路：细胞的调节器，药物的靶点，科学的前沿 - 知乎
2023年9月26日 · mTOR是哺乳动物 雷帕霉素 靶蛋白（mammalian target of rapamycin）的缩写，它是一种丝氨酸/苏氨酸蛋白激酶，属于 PI3K/Akt信号通路 的下游效应子。mTOR可以与不 …