CD20 is a transmembrane protein consisting of four hydrophobic transmembrane domains, one intracellular domain and two extracellular loops. There are three different forms of CD20 according to variable phosphorylation. CD20 is located on the cell surface as homo-dimeric and homo-tetrameric oligomers.

Apr 19, 2022 · CD20 is a CD marker—a molecule on the cell surface that can be used to identify and type a particular cell in the body. CD20 is found on the surface of B cells, but let's back up and make this easier to understand.

CD20 is a general B-cell marker expressed by the majority of B cells starting from late pre-B lymphocytes (it is not expressed by pro-B lymphocytes), and its expression is lost in terminally differentiated plasmablasts and plasma cells.

CD20 is a membrane-embedded surface molecule that is involved in the development and differentiation of B-cells into plasma cells. It is expressed on B-cells throughout their differentiation process until they become plasma cells.

The success of RTX has led to a general interest in the mechanism of action of CD20 mAbs. CD20 mAbs can induce tumor killing via various mechanisms, such as direct induction of apoptosis, antibody-dependent cell-mediated cytotoxicity (ADCC) or …

Feb 16, 2021 · CD20 is a B cell-specific membrane protein and represents an attractive target for therapeutic antibodies. Despite widespread usage of anti-CD20 antibodies for B cell depletion therapies, the biological function of their target remains unclear.

5 days ago · Understanding CD20’s biological role, expression patterns, and regulatory mechanisms provides insight into normal immune responses and disease processes. Biological Significance Of CD20. CD20 is a non-glycosylated phosphoprotein expressed on B cells from the pre-B cell stage through maturity but absent on plasma cells.

CD20 is a protein primarily expressed on the surface of B cells, a type of white blood cell that plays a key role in the immune system’s defense against infections.

Confirming complete absence of B cells in suspected primary humoral immunodeficiencies using both CD19 and CD20 markers.

CD20 is a cell surface protein primarily found on B-lymphocytes (B-cells), which are essential white blood cells in the adaptive immune system. CD20 plays a crucial role in regulating B-cell activation, growth, and differentiation, particularly in the immune response to pathogens.