CD25 bright NK cells display superior function and metabolic …
2023年3月22日 · Regulatory T (Treg) cells suppress NK cell activity through various mechanisms including deprivation of IL-2 via the IL-2 receptor alpha (CD25). Here, we investigate CD25 …
CD25 (IL-2R) expression correlates with the target cell induced ...
Here, we propose the CD25 receptor as a candidate for NK cell cytotoxicity marker. We have verified that there is a correlation between classic target cell induced cytotoxicity markers and …
CD69、CD25、CD38、HLA-DR这四个细胞活化标记的意义和区别？
2021年4月7日 · CD25是IL-2受体的α链，在外周血淋巴细胞的几个亚群表面呈组成性表达，例如调节性和静息记忆T细胞。 在刺激TCR/CD3复合物的24小时内上调，并在几天内保持升 …
CD25 bright NK cells display superior function and metabolic …
2023年3月22日 · The intratumor CD25 bright NK cells display significantly higher levels of proliferation in Treg containing tumor spheroids (figure 3f). Collectively, these results show that …
Cytokine Activation Induces CD25 Expression and a Signaling …
2012年11月16日 · Here, we report the induction of CD25, and a signal-competent high-affinity component of the IL-2 receptor, on CD56 dim human NK cells, following cytokine pre …
CD25 (IL2RA) 是激活的人类自然杀伤细胞中 PRDM1 的直接转录靶 …
2018年11月29日 · CD25 表达在 NK92 和 KHYG1 细胞系中被两种不同的 shRNA 稳定地敲低。 CD25 在通过与 K562-Cl9-mb21 共培养激活的原代人 NK 细胞中异位表达。 分别对 CD25 …
Multi-cellular natural killer (NK) cell clusters enhance NK cell ...
2017年1月11日 · Live cell imaging of lytic granules revealed their dynamic and prolonged polarization toward neighboring NK cells without degranulation. These results suggest that IL …
【靶点Talk】CD25：肿瘤免疫疗法新势力 - 知乎 - 知乎专栏
cd25抑制剂临床主要运用于自身免疫病以及器官移植的免疫排斥（针对效应t细胞），未来有望拓宽至肿瘤领域（针对调节性t细胞）。 临床靶向CD25的药物有单抗、抗体放射性结合物、ADC …
Functional significance of the activation-associated receptors CD25 …
Together, our data suggest that CD69 is a useful marker for cytotoxic activity of NK cells, whereas proliferative potential is indicated by CD25 expression. These findings should help optimizing …
Preactivation with IL-12, IL-15, and IL-18 Induces CD25 and a ...
2014年4月1日 · IL-15 or IL-18 alone enhanced the percentage of NK cells expressing CD25, but again resulted in a small increase in per cell expression (mean fluorescence intensity [MFI]). …