CD28主要作为“第二信号” （与靶细胞表面的B7-1/ B7-2结合） 降低有效活化T细胞所需的阈值，强化激活T细胞的“第一信号” （T细胞受体（TCR）- CD3复合物对靶细胞的MHC-多肽识别和结 …

CD80及CD86与T细胞表面的受体CD28蛋白结合，给与初始T细胞活化的信号，产生刺激效应：促使T细胞活化、增殖与分化；诱导T细胞表面IL-2受体上调，增加IL-2 mRNA的转录，促进细胞 …

2001年11月19日 · CD28 is a homodimeric type 1 transmembrane protein that is a member of the immunoglobulin (Ig) superfamily and has a single Ig-like domain. CD28 interacts with CD80 …

1997年2月3日 · The structurally related T cell surface molecules CD28 and CTLA-4 interact with cell surface ligands CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells (APC) and …

2022年4月4日 · To address this, here we utilize directed evolution to engineer a CD80 IgV domain with increased PD-L1 affinity and fuse this to an immunoglobulin Fc domain, creating a …

This article reviews the CD28/CTLA4 and CD80/CD86 families, and outlines the functional outcomes and biochemical signaling pathways recruited after CD28 ligation. T cell stimulation …

2018年7月31日 · The simulations predict a mechanism of CD28 movement, according to which CD28-CD80 complexes passively follow TCR-pMHC microclusters. However, the …

2023年3月6日 · CD28是TCR激活后T细胞信号传导关键介质，CD28与其配体CD80/CD86结合后，激活并驱动T细胞功能、增殖和存活的下游信号。 而除了作为T细胞活化的第二信号外，近 …

2014年12月15日 · In this study, we show that Tregs form stable conjugates with DCs before, but not after, they decrease surface expression of the costimulatory molecule CD80 on the DCs. …

The ligands or counterreceptors for these two proteins are the B7 family members, CD80 (B7-1) and CD86 (B7-2). This article reviews the CD28/CTLA4 and CD80/CD86 families, and outlines …