2021年4月1日 · CD28.OX40 costimulatory combination is ultimately responsible for the antitumor efficacy of the approach, paving the way to translate this therapeutic strategy in patients with CD30+ HL and NHL.

ox40通过 tcr 、 cd28 /cd80、 cd40 /cd40l等信号在t细胞上诱导表达，并在t细胞激活后的48-72小时达到峰值。 tcr信号传导可以启动多种细胞上ox40的表达，cd28和其他细胞因子可以进一步促进其在活化的t细胞上的表达。也有报道称， il-2 、il-4和tnf可以增强或延长ox40的表达。

2020年2月29日 · CD28 是首个被靶向的共刺激受体，在T细胞表面表达，在抗原呈递细胞 (APC)“刺激”T细胞受体 (TCR)后提供第二信号。 一旦TCR和CD28都被触发，T细胞就准备分泌免疫刺激干扰素并释放穿孔素和颗粒酶来溶解肿瘤细胞。 遗憾的是，科学家们希望通过增强CD28信号来提升抗癌作用的想法却带来了“灾难”。 2006年，TeGenero的 CD28超激动剂抗体在6名健康I期志愿者中引起了大量的细胞因子风暴和多器官衰竭。 因为该抗体激活T细胞无需“TCR参与”， …

2004年6月1日 · Targeting the T-cell co-stimulatory molecules CD28 and OX40 is a promising strategy for controlling T-cell-mediated immune disorders, by regulating the T cells that cause disease.

1999年6月15日 · We found that OX40 can be expressed on anti-CD3-stimulated T cells without costimulation with anti-CD28 mAb (Fig. 3,A) and also on CD28 − T cells from CD28-deficient mice (Fig. 3,D). This independence of OX40 expression from CD28 costimulation underlies the CD28-independent costimulatory activity of OX40L as represented in Fig. 6 .

2017年3月21日 · OX40 acts as an alternative costimulator of CD4 + CD28 - T cells and plays a pathogenic role in autoimmune arthritic development, suggesting that it is a potential target for immunomodulatory therapy of RA.

OX40 acts as an alternative costimulator of CD4 + CD28 − T cells and plays a pathogenic role in autoimmune arthritic development, suggesting that it is a potential target for immunomodulatory therapy of RA. The online version of this article (doi:10.1186/s13075-017-1261-9) contains supplementary material, which is available to authorized users.

2021年4月1日 · The CD28.OX40 co-stimulatory combination is ultimately responsible for the anti-tumor efficacy of the approach, paving the way to translate this therapeutic strategy into clinical use for patients with CD30 + HL and NHL.

2022年4月1日 · In this study, we designed and constructed a series of BCMA-targeting second-generation CAR constructs containing CD28, 41BB, and OX40 molecules, respectively, to identify the costimulatory domains most favorable for persistence.

2023年3月6日 · cd28是tcr激活后t细胞信号传导关键介质，cd28与其配体cd80/cd86结合后，激活并驱动t细胞功能、增殖和存活的下游信号。 而除了作为T细胞活化的第二信号外，近年来研究还发现CD28通路的激活针对PD-1/-L1的免疫治疗也有重大意义。