2008年8月15日 · CD28 is required for the development of regulatory T cells (Tregs; CD4(+)CD25(+)Foxp3(+)) in the thymus and also contributes to their survival and homeostasis in the periphery. We studied whether and how CD28 and ICOS control the differentiation of Tregs from naive T cells.

The costimulatory molecule CD28 is required for optimal activation and function of naive T cells; however, its role in Treg function has been difficult to dissect, as CD28 is required for thymic Treg development, and blockade of CD28-ligand interactions has confounding effects in trans on nonregulatory cells.

2017年2月22日 · As single-CD28 stimulation led to limited expansion rates, we examined a CD28-superagonist antibody and demonstrate a significant increased Treg expansion that was more efficient than...

OSE Immuno的FR104靶向CD28配体结合基序重叠表位MYPPPY，抑制CD28与B7-1/B7-2的结合途径，下调效应T细胞，同时能促进调节性T细胞（T-Reg）活性。1期临床研究已显示出有效性，良好的安全性和2期推荐剂量的初步信号，进一步支持了该资产在自身免疫性疾病或移植中的 ...

Here, we discuss recent insights into the molecular events underlying CD28-mediated co-stimulation, its impact on gene regulation, and the differential role of CD28 expression on Treg cells versus conventional CD4 + and CD8 + T-cells. Moreover, we summarize the exciting therapeutic options which have arisen from our current understanding of T ...

2021年2月15日 · By titrating CD28 stimulation, we found that above a certain concentration (approximately 0.05 μg ml −1), anti-CD28 slows the proliferation of T cells, especially in low glucose concentrations...

CD28 ligation leads to unique epigenetic, transcriptional, and post-translational changes in T cells that cannot be recapitulated by TCR ligation alone. We discuss the function of CD28 and its ligands in both effector and regulatory T cells. CD28 is critical for regulatory T cell survival and the maintenance of immune homeostasis.

2021年11月1日 · A subset of CD8 + Tregs that lack the surface expression of CD28 (CD8 + CD28 − Treg) has proved efficacious in preclinical models. CD8 + CD28 − Tregs are present in healthy individuals, but their impaired functionality in disease renders them less effective in mediating immunosuppression.

2017年1月22日 · Two distinct CD8-expressing Treg populations can be distinguished based on expression of the co-stimulatory receptor CD28. Here, we review the literature on these (at least in part) thymus-derived CD28 low and peripherally induced CD28 − CD8 + Tregs.

2018年1月29日 · Growing evidence suggests that CD8+CD28- T cells are a unique subpopulation of regulatory T cells (Tregs) that exert broad effects on directly regulating T cells, such as by inhibiting their...